实验性诱导过敏性哮喘的药理学调节

Pharmacologic modulation of experimentally induced allergic asthma.

作者信息

Fraňová Soňa, Strapková Anna, Mokrý Juraj, Sutovská Martina, Jošková Marta, Sadloňová Vladimíra, Antošová Martina, Pavelčíková Darina, Flešková Dana, Nosáĺová Gabriela

机构信息

Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.

出版信息

Interdiscip Toxicol. 2011 Mar;4(1):27-32. doi: 10.2478/v10102-011-0006-x.

DOI:10.2478/v10102-011-0006-x

PMID:21577281

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3090051/

Abstract

Allergic asthma is the most frequent disease of the respiratory tract. The aim of the current experimental and clinical studies was to find new sources of drugs able to control asthmatic inflammation and airway hyperresponsiveness. Our experimental studies were focused on efficiency evaluation of substances able to influence activities of ion channels, phosphodiesterase (PDE) isoforms, substances from the group of polyphenols and NO metabolism modulators during experimentally induced allergic asthma.

摘要

过敏性哮喘是呼吸道最常见的疾病。当前实验和临床研究的目的是寻找能够控制哮喘炎症和气道高反应性的新药物来源。我们的实验研究集中于评估在实验性诱导的过敏性哮喘期间，能够影响离子通道活性、磷酸二酯酶（PDE）亚型、多酚类物质和一氧化氮（NO）代谢调节剂活性的物质的效能。