Whitworth J A, Hewitson T D, Ming L, Wilson R S, Scoggins B A, Wright R D, Kincaid-Smith P
Department of Nephrology, Royal Melbourne Hospital, Australia.
J Hypertens. 1990 Jan;8(1):27-36. doi: 10.1097/00004872-199001000-00006.
Adrenocorticotrophin (ACTH) administration has been systematically studied in man and sheep. It raises systolic blood pressure (SBP) in the rat, but this has been little studied. ACTH was injected once daily at 0.5 mg/kg for 12 days in male Sprague-Dawley rats (n = 19). Sham-injected animals were studied in parallel (n = 15). ACTH increased SBP from 94 +/- 4 to 121 +/- 4 mmHg (P less than 0.001), significantly greater (P less than 0.02) than sham injection. The SBP of ACTH-treated rats was significantly higher than that of sham-injected rats when the same animals were measured by both the tail-cuff method (ACTH, 126 +/- 3 mmHg; sham, 99 +/- 3 mmHg) and direct arterial cannulation (ACTH, 137 +/- 2 mmHg; sham, 123 +/- 3 mmHg): P less than 0.005 and P less than 0.001, respectively. There was a loss of body weight, and increased water intake and urine output in ACTH-treated animals compared with both control (P less than 0.001) and sham treatments (P less than 0.02). ACTH increased plasma [Na] (sham, 140 +/- 1 mmol/l; ACTH, 145 +/- 1 mmol/l; P less than 0.001) and urinary Na excretion compared with control (P less than 0.01) and sham injection (P less than 0.05), and also decreased plasma [K] (sham, 4.6 +/- 0.2 mmol/l; ACTH, 3.3 +/- 0.8 mmol/l; P less than 0.01) and increased urinary K excretion (P less than 0.01) compared with control. SBP in adrenalectomized animals (n = 10) was unchanged by ACTH. ACTH increased adrenal, renal, cardiac and brain weights compared with sham injection (P less than 0.05). There were no significant changes in vascular morphology, although ACTH treatment increased glomerular epithelial cell droplets and abolished the adrenal zona glomerulosa.
已在人和绵羊身上系统研究了促肾上腺皮质激素（ACTH）的给药情况。它可使大鼠收缩压（SBP）升高，但对此研究较少。对雄性Sprague-Dawley大鼠（n = 19）每天注射一次0.5 mg/kg的ACTH，持续12天。同时对假注射动物进行平行研究（n = 15）。ACTH使SBP从94±4 mmHg升高至121±4 mmHg（P<0.001），显著高于假注射组（P<0.02）。当通过尾袖法（ACTH组，126±3 mmHg；假注射组，99±3 mmHg）和直接动脉插管法（ACTH组，137±2 mmHg；假注射组，123±3 mmHg）对同一批动物进行测量时，ACTH处理组大鼠的SBP显著高于假注射组大鼠，P值分别<0.005和<0.001。与对照组（P<0.001）和假处理组（P<0.02）相比，ACTH处理组动物体重减轻，饮水量和尿量增加。与对照组相比，ACTH使血浆[Na]升高（假注射组，140±1 mmol/L；ACTH组，145±1 mmol/L；P<0.001），尿钠排泄增加（P<0.01），与假注射组相比也增加（P<0.05），同时使血浆[K]降低（假注射组，4.6±0.2 mmol/L；ACTH组，3.3±0.8 mmol/L；P<0.01），尿钾排泄增加（P<0.01）。肾上腺切除动物（n = 10）的SBP不受ACTH影响。与假注射相比，ACTH使肾上腺、肾脏、心脏和脑重量增加（P<0.05）。血管形态无显著变化，尽管ACTH处理增加了肾小球上皮细胞液滴并使肾上腺球状带消失。
