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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Apr;18(4):197-204. doi: 10.1111/j.1440-1681.1991.tb01432.x.

The effect of chemical sympathectomy with 6-OH-dopamine (6-OHDA) on the onset of adrenocorticotrophin (ACTH)-induced hypertension was examined in Sprague-Dawley rats (n = 23). 2. 6-OHDA injection produced a fall in systolic blood pressure (SBP) from 100 +/- 5 mmHg control to 74 +/- 4 mmHg post-6-OHDA Treatment Day 1 (P less than 0.001), but did not alter food or water intake, urine volume or electrolyte excretion. 3. Compared with sham injection, ACTH-treated rats showed an increase in blood pressure (sham: 98 +/- 7 mmHg; ACTH: 123 +/- 9 mmHg on Treatment Day 10; P less than 0.01), loss of bodyweight, and increases in water intake and urine volume. 4. The magnitude of the blood pressure rise on ACTH was greater in 6-OHDA-treated rats than in intact control rats. Metabolic changes were similar. 5. Chemical sympathectomy with 6-OHDA did not delay or block the onset of ACTH hypertension in the rat.

在23只Sprague-Dawley大鼠中，研究了用6-羟基多巴胺（6-OHDA）进行化学性交感神经切除术对促肾上腺皮质激素（ACTH）诱导的高血压发病的影响。2. 注射6-OHDA后，收缩压（SBP）从对照时的100±5 mmHg降至6-OHDA治疗第1天的74±4 mmHg（P<0.001），但未改变食物或水摄入量、尿量或电解质排泄。3. 与假注射相比，ACTH治疗的大鼠血压升高（假注射：治疗第10天为98±7 mmHg；ACTH：为123±9 mmHg；P<0.01），体重减轻，水摄入量和尿量增加。4. 6-OHDA治疗的大鼠中ACTH引起的血压升高幅度大于完整对照大鼠。代谢变化相似。5. 用6-OHDA进行化学性交感神经切除术并未延迟或阻止大鼠ACTH高血压的发病。

Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1991 Apr;18(4):197-204. doi: 10.1111/j.1440-1681.1991.tb01432.x.

The effect of chemical sympathectomy with 6-OH-dopamine (6-OHDA) on the onset of adrenocorticotrophin (ACTH)-induced hypertension was examined in Sprague-Dawley rats (n = 23). 2. 6-OHDA injection produced a fall in systolic blood pressure (SBP) from 100 +/- 5 mmHg control to 74 +/- 4 mmHg post-6-OHDA Treatment Day 1 (P less than 0.001), but did not alter food or water intake, urine volume or electrolyte excretion. 3. Compared with sham injection, ACTH-treated rats showed an increase in blood pressure (sham: 98 +/- 7 mmHg; ACTH: 123 +/- 9 mmHg on Treatment Day 10; P less than 0.01), loss of bodyweight, and increases in water intake and urine volume. 4. The magnitude of the blood pressure rise on ACTH was greater in 6-OHDA-treated rats than in intact control rats. Metabolic changes were similar. 5. Chemical sympathectomy with 6-OHDA did not delay or block the onset of ACTH hypertension in the rat.

在23只Sprague-Dawley大鼠中，研究了用6-羟基多巴胺（6-OHDA）进行化学性交感神经切除术对促肾上腺皮质激素（ACTH）诱导的高血压发病的影响。2. 注射6-OHDA后，收缩压（SBP）从对照时的100±5 mmHg降至6-OHDA治疗第1天的74±4 mmHg（P<0.001），但未改变食物或水摄入量、尿量或电解质排泄。3. 与假注射相比，ACTH治疗的大鼠血压升高（假注射：治疗第10天为98±7 mmHg；ACTH：为123±9 mmHg；P<0.01），体重减轻，水摄入量和尿量增加。4. 6-OHDA治疗的大鼠中ACTH引起的血压升高幅度大于完整对照大鼠。代谢变化相似。5. 用6-OHDA进行化学性交感神经切除术并未延迟或阻止大鼠ACTH高血压的发病。