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由口蹄疫病毒三种血清型对应的合成肽诱导的异型保护。

Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.

作者信息

Doel T R, Gale C, Do Amaral C M, Mulcahy G, Dimarchi R

机构信息

Agricultural and Food Research Council Institute for Animal Health, Pirbright Laboratory, Woking, United Kingdom.

出版信息

J Virol. 1990 May;64(5):2260-4. doi: 10.1128/JVI.64.5.2260-2264.1990.

DOI:10.1128/JVI.64.5.2260-2264.1990
PMID:2157884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249387/
Abstract

Synthetic peptide vaccines of the general sequence Cys-Cys(200-213)-Pro-Pro-Ser-(141-158)-Pro-Cys-Gly, where the numbered residues refer to VP1 sequences of three different strains of foot-and-mouth disease virus, have been evaluated in cattle and guinea pigs. High levels of serotype-specific (homotypic) antiviral and antipeptide antibody were produced with each peptide. The A- and O-serotype peptides provided complete protection of guinea pigs against their respective virus challenges. The C-serotype peptide appeared to be less effective than the other peptides. In cross-protection studies (heterotypic) in guinea pigs, it was possible to protect A-serotype peptide-vaccinated animals against O-virus challenge and vice versa. Some heterotypic protection was also achieved with the C-serotype peptide. The heterotypic protection observed related more to the presence of cross-reactive antipeptide antibody than to neutralizing antibody.

摘要

一般序列为Cys-Cys(200 - 213)-Pro-Pro-Ser-(141 - 158)-Pro-Cys-Gly的合成肽疫苗已在牛和豚鼠身上进行了评估，其中编号的残基指三种不同口蹄疫病毒株的VP1序列。每种肽都产生了高水平的血清型特异性（同型）抗病毒和抗肽抗体。A和O血清型肽为豚鼠提供了针对各自病毒攻击的完全保护。C血清型肽似乎比其他肽效果差。在豚鼠的交叉保护研究（异型）中，有可能保护接种A血清型肽的动物免受O病毒攻击，反之亦然。C血清型肽也实现了一些异型保护。观察到的异型保护更多地与交叉反应性抗肽抗体的存在有关，而不是与中和抗体有关。

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本文引用的文献

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Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence.通过用根据病毒核苷酸序列预测的化学合成肽进行免疫接种来预防口蹄疫。
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Location and characterization of the antigenic portion of the FMDV immunizing protein.口蹄疫病毒免疫蛋白抗原部分的定位与特性分析
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A physico-chemical sub-grouping of the mammalian picornaviruses.哺乳动物微小核糖核酸病毒的物理化学亚分组。
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Correlation of 140S antigen dose with the serum neutralizing antibody response and the level of protection induced in cattle by foot-and-mouth disease vaccines.口蹄疫疫苗中140S抗原剂量与牛血清中和抗体反应及诱导的保护水平的相关性
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