由口蹄疫病毒三种血清型对应的合成肽诱导的异型保护。
Heterotypic protection induced by synthetic peptides corresponding to three serotypes of foot-and-mouth disease virus.
作者信息
Doel T R, Gale C, Do Amaral C M, Mulcahy G, Dimarchi R
机构信息
Agricultural and Food Research Council Institute for Animal Health, Pirbright Laboratory, Woking, United Kingdom.
出版信息
J Virol. 1990 May;64(5):2260-4. doi: 10.1128/JVI.64.5.2260-2264.1990.
Abstract
Synthetic peptide vaccines of the general sequence Cys-Cys(200-213)-Pro-Pro-Ser-(141-158)-Pro-Cys-Gly, where the numbered residues refer to VP1 sequences of three different strains of foot-and-mouth disease virus, have been evaluated in cattle and guinea pigs. High levels of serotype-specific (homotypic) antiviral and antipeptide antibody were produced with each peptide. The A- and O-serotype peptides provided complete protection of guinea pigs against their respective virus challenges. The C-serotype peptide appeared to be less effective than the other peptides. In cross-protection studies (heterotypic) in guinea pigs, it was possible to protect A-serotype peptide-vaccinated animals against O-virus challenge and vice versa. Some heterotypic protection was also achieved with the C-serotype peptide. The heterotypic protection observed related more to the presence of cross-reactive antipeptide antibody than to neutralizing antibody.
摘要
一般序列为Cys-Cys(200 - 213)-Pro-Pro-Ser-(141 - 158)-Pro-Cys-Gly的合成肽疫苗已在牛和豚鼠身上进行了评估，其中编号的残基指三种不同口蹄疫病毒株的VP1序列。每种肽都产生了高水平的血清型特异性（同型）抗病毒和抗肽抗体。A和O血清型肽为豚鼠提供了针对各自病毒攻击的完全保护。C血清型肽似乎比其他肽效果差。在豚鼠的交叉保护研究（异型）中，有可能保护接种A血清型肽的动物免受O病毒攻击，反之亦然。C血清型肽也实现了一些异型保护。观察到的异型保护更多地与交叉反应性抗肽抗体的存在有关，而不是与中和抗体有关。
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