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使用肽进行口蹄疫免疫接种。

Use of peptides for immunization against foot-and-mouth disease.

作者信息

Brown F

机构信息

Wellcome Biotechnology Ltd, Pirbright, Surrey, UK.

出版信息

Vaccine. 1988 Apr;6(2):180-2. doi: 10.1016/s0264-410x(88)80024-0.

DOI:10.1016/s0264-410x(88)80024-0
PMID:2838987
Abstract

A peptide corresponding to the major immunogenic site of the protein VP1 of foot-and-mouth disease virus (FMDV) will elicit a protective neutralizing antibody response in guinea-pigs, cattle and pigs. The response is much greater when the peptide is presented as a linear dimer or tetramer and pigs receiving as little as 40 micrograms peptide have been protected against challenge infection. An even greater response is obtained when the peptide is presented as part of the core protein of hepatitis B virus. Moreover, responsiveness to the peptide in non-responder mice can be stimulated by the simultaneous inoculation of an appropriate T-cell epitope linked to the FMDV peptide.

摘要

一种与口蹄疫病毒（FMDV）蛋白VP1的主要免疫原性位点相对应的肽，能在豚鼠、牛和猪体内引发保护性中和抗体反应。当该肽以线性二聚体或四聚体形式呈现时，反应会大得多，并且接受低至40微克该肽的猪已受到保护，免受攻击感染。当该肽作为乙型肝炎病毒核心蛋白的一部分呈现时，会获得更大的反应。此外，通过同时接种与FMDV肽相连的合适T细胞表位，可以刺激无反应小鼠对该肽的反应性。

相似文献

1
Use of peptides for immunization against foot-and-mouth disease.使用肽进行口蹄疫免疫接种。
Vaccine. 1988 Apr;6(2):180-2. doi: 10.1016/s0264-410x(88)80024-0.
2
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.针对豚鼠和猪口蹄疫病毒感染的重组融合蛋白及DNA疫苗。
Viral Immunol. 1999;12(1):1-8. doi: 10.1089/vim.1999.12.1.
3
[Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22].[口蹄疫病毒的抗原结构。II. A22型口蹄疫病毒VP1蛋白主要免疫原区保护性肽的合成]
Bioorg Khim. 1988 Oct;14(10):1363-71.
4
[Antigenic structure of the foot-and-mouth-disease virus. I. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth virus type O1K].[口蹄疫病毒的抗原结构。I. 从O1K型口蹄疫病毒VP1蛋白主要免疫原性区域合成保护性肽段]
Bioorg Khim. 1988 Oct;14(10):1352-62.
5
Liposome encapsulated subunit (VP1) and virion vaccines against foot-and-mouth disease.用于预防口蹄疫的脂质体包裹亚基（VP1）疫苗和病毒粒子疫苗。
Acta Virol. 1987 Mar;31(2):109-15.
6
Characterization and immune response of a protein produced by a cDNA clone of foot and mouth disease virus, type Asia 1 63/72.
Biochem Int. 1992 May;26(6):1003-16.
7
Synthetic peptides as potential vaccines against foot-and-mouth disease.合成肽作为抗口蹄疫的潜在疫苗。
Endeavour. 1990;14(2):87-94. doi: 10.1016/0160-9327(90)90077-5.
8
[Antigenic structure of the foot-and-mouth virus. V. Protection of naturally susceptible animals from foot-and-mouth disease using a synthetic peptide].
Bioorg Khim. 1989 Oct;15(10):1313-7.
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Synthetic peptides against foot-and-mouth disease--immunization with VP1-peptides of type O1-Kaufbeuren.抗口蹄疫合成肽——用O1-考夫博伊伦型VP1肽进行免疫接种
Arch Exp Veterinarmed. 1990;44(6):883-90.
10
Fusion proteins with multiple copies of the major antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animals.含有口蹄疫病毒主要抗原决定簇多个拷贝的融合蛋白可保护天然宿主和实验动物。
J Gen Virol. 1987 Dec;68 ( Pt 12):3137-43. doi: 10.1099/0022-1317-68-12-3137.

引用本文的文献

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2
B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development.入侵性口蹄疫病毒血清型 SAT2 的 B 和 T 细胞表位，用于疫苗开发。
Viruses. 2023 Mar 21;15(3):797. doi: 10.3390/v15030797.
3
A meta-analysis: the efficacy and effectiveness of polypeptide vaccines protect pigs from foot and mouth disease.
一项荟萃分析：多肽疫苗预防猪口蹄疫的效果和效力。
Sci Rep. 2022 Dec 19;12(1):21868. doi: 10.1038/s41598-022-26462-x.
4
Neutralizing antiviral antibody responses.中和抗病毒抗体反应。
Adv Immunol. 2001;79:1-53. doi: 10.1016/s0065-2776(01)79001-3.
5
Circular dichroism, molecular modeling, and serology indicate that the structural basis of antigenic variation in foot-and-mouth disease virus is alpha-helix formation.圆二色性、分子建模和血清学表明，口蹄疫病毒抗原变异的结构基础是α-螺旋的形成。
Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8442-6. doi: 10.1073/pnas.91.18.8442.
6
Need for cellular and humoral immune responses in bovines to ensure protection from foot-and-mouth disease virus (FMDV)--a point of view.牛产生细胞免疫和体液免疫反应以确保抵御口蹄疫病毒（FMDV）的必要性——一种观点。
Virus Genes. 1994 Jul;8(3):199-214. doi: 10.1007/BF01703078.