Hammerschmidt W, Sugden B
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Mol Biol Med. 1990 Feb;7(1):45-57.
We have two goals in this review: the first is to relate what has been learned about DNA replication from the study primarily of herpes simplex virus type 1 (HSV-1); the second is to note briefly facets of this virus's mode of DNA replication that might serve as points of intervention for novel chemotherapeutic approaches in order to deal with primary and recurrent herpesvirus infections in man and animals. For the first goal we shall both summarize what has been learned and attempt to identify directions that may be pursued in order to further our understanding of DNA replication by herpesviruses. For the second goal we shall propose two schemes for the screening for drugs that might interfere uniquely with the DNA replication of this family of viruses.
在本综述中，我们有两个目标：第一个目标是阐述主要通过对1型单纯疱疹病毒（HSV-1）的研究而了解到的有关DNA复制的知识；第二个目标是简要指出该病毒DNA复制模式的一些方面，这些方面可能作为新型化疗方法的干预点，以应对人和动物的原发性及复发性疱疹病毒感染。对于第一个目标，我们将既总结已学到的知识，又尝试确定可以探索的方向，以便进一步了解疱疹病毒的DNA复制。对于第二个目标，我们将提出两种筛选药物的方案，这些药物可能会特异性地干扰该病毒家族的DNA复制。
