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单纯疱疹病毒基因组异构化：串联病毒DNA中相邻长片段的起源

Herpes simplex virus genome isomerization: origins of adjacent long segments in concatemeric viral DNA.

作者信息

Slobedman B, Zhang X, Simmons A

机构信息

Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia.

出版信息

J Virol. 1999 Jan;73(1):810-3. doi: 10.1128/JVI.73.1.810-813.1999.

DOI:10.1128/JVI.73.1.810-813.1999
PMID:9847394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC103895/
Abstract

Herpes simplex virus type 1 DNA isomerization was studied by using a viral mutant, 5B8, lacking the unique SpeI site of its parent, SC16. In coinfected cells, SC16 genomic long segments flanked 5B8 genomes in all possible orientations with similar frequencies. Thus, recombination between progeny of different replication templates is sufficient to explain genomic isomerization.

摘要

利用一种病毒突变体5B8对1型单纯疱疹病毒DNA异构化进行了研究，该突变体缺乏其亲本SC16的独特SpeI位点。在共感染的细胞中，SC16基因组的长片段以相似的频率在所有可能的方向上位于5B8基因组两侧。因此，不同复制模板后代之间的重组足以解释基因组异构化。

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Herpes simplex virus genome isomerization: origins of adjacent long segments in concatemeric viral DNA.单纯疱疹病毒基因组异构化：串联病毒DNA中相邻长片段的起源
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本文引用的文献

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Direct repeats of the herpes simplex virus a sequence promote nonconservative homologous recombination that is not dependent on XPF/ERCC4.单纯疱疹病毒a序列的直接重复促进了非保守性同源重组，这种重组不依赖于XPF/ERCC4。
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J Virol. 1996 Dec;70(12):8801-12. doi: 10.1128/JVI.70.12.8801-8812.1996.
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