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3-异丁基 5-甲基 2,6-二甲基-4-(2-硝基苯基)吡啶-3,5-二羧酸酯

3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitro-phen-yl)pyridine-3,5-dicarboxyl-ate.

作者信息

Chen Hui, Luo Jing, Jing Lin-Lin, Jiang Ru

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 9;66(Pt 1):o86. doi: 10.1107/S1600536809051988.

DOI:10.1107/S1600536809051988
PMID:21580183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2980128/
Abstract

The title nitro-phenyl pyridine compound, C(20)H(22)N(2)O(6) was synthesized as a degradation product of the hypertension medication nisoldipine. The dihedral angle between the nitro-substituted phenyl ring and the pyridine ring is 75.5 (4)°. There are a number of C-H⋯O inter-actions between symmetry-related mol-ecules>.

摘要

标题为硝基苯基吡啶化合物C(20)H(22)N(2)O(6)是作为高血压药物尼索地平的降解产物合成的。硝基取代苯环与吡啶环之间的二面角为75.5 (4)°。对称相关分子之间存在大量C-H⋯O相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b1f/2980128/913ff6f201b6/e-66-00o86-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b1f/2980128/913ff6f201b6/e-66-00o86-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b1f/2980128/913ff6f201b6/e-66-00o86-fig1.jpg

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本文引用的文献

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The effect of ionizing radiation on some derivatives of 1,4-dihydropyridine in the solid state.
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Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552).一种新型钙拮抗化合物——异丁基甲基 1,4 - 二氢 - 2,6 - 二甲基 - 4(2 - 硝基苯基)-3,5 - 吡啶二羧酸酯（尼索地平，Bay k 5552）的药理学
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