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Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552).

作者信息

Kazda S, Garthoff B, Meyer H, Schlossmann K, Stoepel K, Towart R, Vater W, Wehinger E

出版信息

Arzneimittelforschung. 1980;30(12):2144-62.

PMID:7194077
Abstract
摘要

相似文献

1
Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552).一种新型钙拮抗化合物——异丁基甲基 1,4 - 二氢 - 2,6 - 二甲基 - 4(2 - 硝基苯基)-3,5 - 吡啶二羧酸酯（尼索地平，Bay k 5552）的药理学
Arzneimittelforschung. 1980;30(12):2144-62.
2
Calcium agonism, a new mechanism for positive inotropy. Hemodynamic effects and mode of action of BAY K 8644.钙激动作用，一种正性肌力的新机制。BAY K 8644的血流动力学效应及作用方式。
Adv Myocardiol. 1985;6:59-70.
3
[Comparative studies on the basic Ca2+ antagonistic activities of niludipine (Bay a 7168) and nifedipine (Bay a 1040) on the myocardium, myometrium and vessels of smooth muscles (author's transl)].尼鲁地平（Bay a 7168）与硝苯地平（Bay a 1040）对心肌、子宫肌层和平滑肌血管的基础钙离子拮抗活性的比较研究（作者译）
Arzneimittelforschung. 1979;29(2):230-46.
4
Hemodynamic effects of the new vasodilator drug Bay k 5552 in man.新型血管扩张药物Bay k 5552对人体的血流动力学影响。
Arzneimittelforschung. 1980;30(12):2162-4.
5
Antihypertensive and cardiovascular effects of the new dihydropyridine derivative methyl (E)-3-phenyl-2-propen-1-yl-1,4-dihydro-2,6-dimethyl- 4-(3-nitrophenyl)pyridine-3,5-dicarboxylate.新型二氢吡啶衍生物（E）-3-苯基-2-丙烯-1-基-1,4-二氢-2,6-二甲基-4-（3-硝基苯基）吡啶-3,5-二羧酸甲酯的降压及心血管效应
Arzneimittelforschung. 1986;36(1):29-34.
6
Effects of niludipine (Bay a 7168) on the cardiovascular system with a note on its calcium-antagonistic effects.
Arzneimittelforschung. 1979;29(9):1368-73.
7
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.新型水溶性钙拮抗剂（±）-3-（4-烯丙基-1-哌嗪基）-2,2-二甲基丙基 1,4-二氢-2,6-二甲基-4-（3-硝基苯基）-3,5-吡啶二甲酸甲酯二盐酸盐对离体犬动脉反应的影响
Arzneimittelforschung. 1995 Aug;45(8):831-5.
8
Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants.新型1,4 - 二氢吡啶对钙通道的激活作用。正性肌力药或平滑肌兴奋剂的一种新机制。
Arzneimittelforschung. 1983;33(9):1268-72.
9
Nifedipine blocks the voltage dependent potentiation of norepinephrine in vascular smooth muscle.硝苯地平可阻断血管平滑肌中去甲肾上腺素的电压依赖性增强作用。
Proc West Pharmacol Soc. 1983;26:231-3.
10
Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydro-pyridine-3,5-di- carboxylic acid.2,6 - 二甲基 - 4 - (2 - 二氟甲氧基苯基)-1,4 - 二氢吡啶 - 3,5 - 二羧酸酯的合成及其选择性血管舒张特性
Arzneimittelforschung. 1989 Oct;39(10):1185-9.

引用本文的文献

1
1,4-dihydropyridines: the multiple personalities of a blockbuster drug family.1,4 - 二氢吡啶类：一个畅销药物家族的多重特性
Transl Med UniSa. 2012 Oct 11;4:12-26. Print 2012 Sep.
2
3-Isobutyl 5-methyl 2,6-dimethyl-4-(2-nitro-phen-yl)pyridine-3,5-dicarboxyl-ate.3-异丁基 5-甲基 2,6-二甲基-4-(2-硝基苯基)吡啶-3,5-二羧酸酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 9;66(Pt 1):o86. doi: 10.1107/S1600536809051988.
3
A comparison of the acute haemodynamic effects of nisoldipine and nifedipine during treatment with atenolol in patients with coronary artery disease.
冠心病患者在阿替洛尔治疗期间硝苯地平与尼索地平急性血流动力学效应的比较。
Br J Clin Pharmacol. 1993 Oct;36(4):315-21. doi: 10.1111/j.1365-2125.1993.tb00370.x.
4
Comparison of nisoldipine and nifedipine as additional treatment in hypertension inadequately controlled by atenolol.尼索地平与硝苯地平作为阿替洛尔控制不佳的高血压辅助治疗的比较
Postgrad Med J. 1993 Feb;69(808):117-20. doi: 10.1136/pgmj.69.808.117.
5
Acute and chronic effects of the dihydropyridine calcium antagonist nisoldipine on the resting and exercise hemodynamics, neurohumoral parameters, and functional capacity of patients with chronic heart failure.二氢吡啶类钙拮抗剂尼索地平对慢性心力衰竭患者静息和运动血流动力学、神经体液参数及功能能力的急性和慢性影响。
Cardiovasc Drugs Ther. 1993 Feb;7(1):103-10. doi: 10.1007/BF00878317.
6
Improvement of ischemic myocardial dysfunction by nisoldipine.
Cardiovasc Drugs Ther. 1994 May;8 Suppl 2:365-70. doi: 10.1007/BF00877321.
7
Cardioselectivity of calcium antagonists.钙拮抗剂的心脏选择性
Cardiovasc Drugs Ther. 1994 May;8 Suppl 2:353-64. doi: 10.1007/BF00877320.
8
Acute effects of intravenous nisoldipine on left ventricular function after acute myocardial infarction.静脉注射尼索地平对急性心肌梗死后左心室功能的急性影响。
Cardiovasc Drugs Ther. 1994 May;8 Suppl 2:345-51. doi: 10.1007/BF00877319.
9
Future prospects for calcium antagonists.
Drugs. 1994;48 Suppl 1:32-9. doi: 10.2165/00003495-199400481-00008.
10
Energy conservation by nisoldipine in ischaemic heart.尼索地平对缺血性心脏的能量守恒作用。
Br J Pharmacol. 1984 Dec;83(4):943-9. doi: 10.1111/j.1476-5381.1984.tb16535.x.