在非人类灵长类动物中使用聚焦超声和微泡进行无创空化引导血脑屏障开放的可行性。
Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates.
作者信息
Tung Yao-Sheng, Marquet Fabrice, Teichert Tobias, Ferrera Vincent, Konofagou Elisa E
出版信息
Appl Phys Lett. 2011 Apr 18;98(16):163704. doi: 10.1063/1.3580763. Epub 2011 Apr 20.
Abstract
In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.
摘要
在此报告了在非人灵长类动物中进行体内经颅和无创空化检测以及血脑屏障（BBB）开放的情况。使用聚焦超声（FUS）结合微泡经颅打开猴子的血脑屏障。一个与FUS换能器共聚焦的被动空化探测器用于识别和监测气泡行为。在超声处理过程中，发现空化谱与区域、压力和气泡有关，可提供关于开放发生及其特性的实时反馈。这些发现证明了在非侵入性人类应用中使用FUS和微泡进行经颅、空化引导的血脑屏障开放的可行性。
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