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N-（4-甲基-2-吡啶基）-叔丁基氨基甲酸酯

tert-Butyl N-(4-methyl-2-pyrid-yl)-carbamate.

作者信息

Koch Pierre, Schollmeyer Dieter, Laufer Stefan

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 31;64(Pt 11):o2216. doi: 10.1107/S1600536808032327.

DOI:10.1107/S1600536808032327
PMID:21581073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2959623/
Abstract

The crystal structure of the title compound, C(11)H(16)N(2)O(2), contains two crystallographically independent mol-ecules forming dimers by pairs of inter-molecular N-H⋯N hydrogen bonds. The two mol-ecules are related by a pseudo-twofold axis. The dihedral angle between the pyridine ring and the carbamate plane differs in the two mol-ecules [12.1 (3) and 3.5 (3)°].

摘要

标题化合物C(11)H(16)N(2)O(2)的晶体结构包含两个晶体学独立的分子，它们通过分子间N-H⋯N氢键对形成二聚体。这两个分子通过一个假二次轴相关联。吡啶环与氨基甲酸酯平面之间的二面角在两个分子中有所不同[分别为12.1 (3)°和3.5 (3)°]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bb8/2959623/c0cf4c595f7d/e-64-o2216-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bb8/2959623/c0cf4c595f7d/e-64-o2216-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bb8/2959623/c0cf4c595f7d/e-64-o2216-fig1.jpg

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本文引用的文献

1
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Org Biomol Chem. 2008 Feb 7;6(3):437-9. doi: 10.1039/b717605h. Epub 2007 Dec 21.
2
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
3
New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase.炎症性疾病治疗的新方法：p38丝裂原活化蛋白激酶的小分子抑制剂
4-(2,2-二甲基丙酰胺基)-吡啶-3-基 N,N-二异丙基二硫代氨基甲酸盐的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Aug 30;70(Pt 9):o1069-70. doi: 10.1107/S1600536814019321. eCollection 2014 Sep 1.
4
2,2-Dimethyl-N-(4-methyl-pyridin-2-yl)propanamide.2,2-二甲基-N-(4-甲基吡啶-2-基)丙酰胺
Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 26;70(Pt 3):o351-2. doi: 10.1107/S1600536814003729. eCollection 2014 Mar 1.
Curr Top Med Chem. 2006;6(2):113-49. doi: 10.2174/156802606775270323.
4
Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.2'-苯胺基-4,4'-联吡啶作为c-Jun氨基末端激酶-3选择性抑制剂的设计与合成
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1397-401. doi: 10.1016/j.bmcl.2005.11.039. Epub 2005 Dec 5.
5
Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.新型强效细胞周期蛋白依赖性激酶抑制剂系列[1,3,5]三嗪-吡啶双杂芳基的合成与鉴定
J Med Chem. 2005 Jul 14;48(14):4535-46. doi: 10.1021/jm040214h.
6
Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.吡嗪 - 吡啶双杂芳基作为新型强效血管内皮生长因子受体 -2 抑制剂的合成与发现
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