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1,1-双（4-氟苯基）-3,4-二氢-1H-1,3-恶嗪并[3,4-a]吲哚

1,1-Bis(4-fluoro-phen-yl)-3,4-dihydro-1H-1,3-oxazino[3,4-a]indole.

作者信息

Fu Weijun, Deng Dongsheng, Hong Dongfeng, Wang Zhiqiang, Ji Baoming

机构信息

College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471022, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 31;64(Pt 11):o2227. doi: 10.1107/S160053680803376X.

DOI:10.1107/S160053680803376X
PMID:21581082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2959698/
Abstract

The title compound, C(23)H(17)F(2)NO, which crystallizes with two independent mol-ecules in the asymmetric unit, was prepared by the cyclization of 4-[2-bis-(4-fluoro-phen-yl)methyl-eneamino]but-3-yn-1-ol at room temperature. The mol-ecules display a tripod conformation. The two fluoro-phenyl rings make dihedral angles of 79.26 (2) and 85.87 (1)° [86.53 (1) and 83.67 (2)° in the second mol-ecule] with the indole ring, and the dihedral angles between the fluoro-phenyl rings are 67.74 (2) and 66.33 (2)°, respectively. Furthermore, the indole rings are located on the edge of the respective oxazine half-chair ring systems. Nonconventional C-H⋯π contacts between indole and fluoro-phenyl rings are observed.

摘要

标题化合物C(23)H(17)F(2)NO在不对称单元中由两个独立分子结晶而成，它是通过4-[2-双-(4-氟苯基)亚甲基氨基]丁-3-炔-1-醇在室温下环化制备的。分子呈三脚架构象。两个氟苯环与吲哚环的二面角分别为79.26 (2)和85.87 (1)°[第二个分子中为86.53 (1)和83.67 (2)°]，氟苯环之间的二面角分别为67.74 (2)和66.33 (2)°。此外，吲哚环位于各自恶嗪半椅环系统的边缘。观察到吲哚环与氟苯环之间存在非常规的C-H⋯π接触。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/056d/2959698/139a7b3c0cc9/e-64-o2227-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/056d/2959698/139a7b3c0cc9/e-64-o2227-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/056d/2959698/139a7b3c0cc9/e-64-o2227-fig1.jpg

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本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Neuromodulatory role of serotonin in the ferret thalamus.血清素在雪貂丘脑的神经调节作用。
J Neurophysiol. 2002 Apr;87(4):2124-36. doi: 10.1152/jn.00650.2001.