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4-氯-2-((1R)-1-{[(R)-(2-氯苯基)(环戊基)甲基]氨基}丙基)苯酚

4-Chloro-2-((1R)-1-{[(R)-(2-chlorophen-yl)(cyclo-pent-yl)meth-yl]amino}prop-yl)phenol.

作者信息

Zhang Guang-You, Yang Ting, Xu Bao-Wang, Chen Di-Juan, Wang Wan-Hui

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 13;65(Pt 1):o123. doi: 10.1107/S1600536808042025.

DOI:10.1107/S1600536808042025
PMID:21581584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968043/
Abstract

In the title compound, C(21)H(25)Cl(2)NO, the dihedral angle between the two benzene rings is 33.18 (11)°. The five-membered ring adopts an envelope conformation. There is an intra-molecular O-H⋯N hydrogen bond. In the crystal, mol-ecules are linked by weak N-H⋯Cl hydrogen bonds, forming a helical chain along the c axis.

摘要

在标题化合物C₂₁H₂₅Cl₂NO中，两个苯环之间的二面角为33.18 (11)°。五元环呈信封构象。存在分子内O—H⋯N氢键。在晶体中，分子通过弱N—H⋯Cl氢键相连，沿c轴形成螺旋链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3e2/2968043/61140911fa54/e-65-0o123-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3e2/2968043/fb12bacb0fc4/e-65-0o123-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3e2/2968043/61140911fa54/e-65-0o123-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3e2/2968043/fb12bacb0fc4/e-65-0o123-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3e2/2968043/61140911fa54/e-65-0o123-fig2.jpg

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本文引用的文献

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A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
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Highly enantioselective cyanosilylation of aldehydes catalyzed by novel beta-amino alcohol-titanium complexes.
新型β-氨基醇-钛配合物催化醛的高对映选择性氰基硅烷化反应
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