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（Z）-5-氟-3-[(1H-吡咯-2-基)亚甲基]吲哚啉-2-酮

(Z)-5-Fluoro-3-[(1H-pyrrol-2-yl)methyl-ene]indolin-2-one.

作者信息

Zhang Hongming, Ankati Haribabu, Akubathini Shashidhar Kumar, Biehl Ed

机构信息

Department of Chemistry, Southern Methodist University, Dallas, TX 75275, USA.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 3;65(Pt 1):o8. doi: 10.1107/S1600536808040178.

DOI:10.1107/S1600536808040178
PMID:21581718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2967860/
Abstract

The title compound, C(13)H(9)FN(2)O, a potential neuroprotective agent, consists of an indolinone and a pyrrolyl unit [dihedral angle between the ring planes = 4.9 (1)°]. An intra-molecular hydrogen bond between the carbonyl O atom and the NH group of pyrrole correlates with the Z arrangement of the substituents at the C=C bond. In the crystal, inversion dimers occur, linked by pairs of N-H⋯O bonds.

摘要

标题化合物C(13)H(9)FN(2)O是一种潜在的神经保护剂，由一个吲哚啉酮和一个吡咯单元组成[环平面之间的二面角 = 4.9 (1)°]。羰基O原子与吡咯的NH基团之间的分子内氢键与C=C键处取代基的Z构型相关。在晶体中，通过N-H⋯O键对形成反演二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95c4/2967860/2903fbeeb073/e-65-000o8-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95c4/2967860/a45005d252c8/e-65-000o8-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95c4/2967860/2903fbeeb073/e-65-000o8-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95c4/2967860/a45005d252c8/e-65-000o8-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95c4/2967860/2903fbeeb073/e-65-000o8-fig2.jpg

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