N-环己基-3-(4-羟基-6-氧代-1,6-二氢嘧啶-5-基)-3-对甲苯基丙酰胺
N-Cyclo-hexyl-3-(4-hydr-oxy-6-oxo-1,6-dihydro-pyrimidin-5-yl)-3-p-tolyl-propanamide.
作者信息
Wang Xing-Han, Hao Wen-Juan, Tu Shu-Jiang
机构信息
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, People's Republic of China.
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 14;65(Pt 2):o309. doi: 10.1107/S1600536809001251.
Abstract
In the mol-ecule of the title compound, C(20)H(25)N(3)O(3), the aromatic rings are oriented at a dihedral angle of 88.36 (3)°. The cyclo-hexane ring adopts a chair conformation. In the crystal structure, inter-molecular N-H⋯O and O-H⋯N hydrogen bonds link the mol-ecules. C-H⋯π inter-actions are also present.
摘要
在标题化合物C₂₀H₂₅N₃O₃的分子中，芳环间的二面角为88.36 (3)°。环己烷环呈椅式构象。在晶体结构中，分子间通过N-H⋯O和O-H⋯N氢键相连，同时还存在C-H⋯π相互作用。
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本文引用的文献
1
A short history of SHELX.
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Pyrimidine as constituent of natural biologically active compounds.
Chem Biodivers. 2005 Jan;2(1):1-50. doi: 10.1002/cbdv.200490173.
3
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 2005 Oct;22(5):627-46. doi: 10.1039/b413750g. Epub 2005 Aug 24.
4
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.
Bioorg Med Chem. 2005 Dec 15;13(24):6663-71. doi: 10.1016/j.bmc.2005.07.046. Epub 2005 Sep 1.
5
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
J Med Chem. 2005 Jul 14;48(14):4690-6. doi: 10.1021/jm050291s.
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