Junkergård J, Andersson B, Jónasson H
Department of Physiology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
Acta Physiol Scand. 1990 Mar;138(3):293-9. doi: 10.1111/j.1748-1716.1990.tb08849.x.
The influence of bilaterally narrow, medial forebrain lesions on the increase in plasma cortisol concentration normally seen in response to intravenous angiotensin II was studied in five goats. For comparison, the pre- and post-lesion cortisol responses to intravenous endotoxin were also evaluated. The cortisol response to angiotensin was extinguished in two goats, whereas a slightly attenuated response to endotoxin was still obtained post-lesioning. In these animals the lesions embraced the subfornical organ (SFO), the organum vasculosum of the lamina terminals (OVLT) and the interjacent anterior wall of the third ventricle. In two other goats, in which the SFO was completely destroyed but the OVLT remained largely intact, the lesions caused about 50% reduction of the cortisol response to angiotensin without any concomitant reduction of the response to endotoxin. It is concluded that ACTH-cortisol release in response to systemic angiotensin II is not mediated exclusively by receptors for the octapeptide confined to the SFO. Angiotensin receptors in the OVLT seem to be equally important in this respect.
在五只山羊身上研究了双侧狭窄的内侧前脑病变对静脉注射血管紧张素II后血浆皮质醇浓度通常升高的影响。作为比较，还评估了病变前后静脉注射内毒素时皮质醇的反应。两只山羊对血管紧张素的皮质醇反应消失，而病变后对内毒素的反应仍略有减弱。在这些动物中，病变累及穹窿下器官（SFO）、终板血管器（OVLT）和第三脑室相邻的前壁。在另外两只山羊中，SFO被完全破坏，但OVLT基本保持完整，病变导致对血管紧张素的皮质醇反应降低约50%，而对内毒素的反应没有任何相应降低。得出的结论是，对全身性血管紧张素II的促肾上腺皮质激素-皮质醇释放并非仅由局限于SFO的八肽受体介导。在这方面，OVLT中的血管紧张素受体似乎同样重要。
