Andersson B, Eriksson S, Rundgren M
Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Acta Physiol Scand. 1995 Oct;155(2):117-25. doi: 10.1111/j.1748-1716.1995.tb09956.x.
A brief account for the renal renin-angiotensin system (RAS), its inhibitors and receptors, as for the presence of an intrinsic cerebral RAS is initially provided. The review is then focused upon the circumventricular organs as cerebral targets for blood-borne angiotensin II (Ang II) and on centrally mediated Ang II effects. These concern influences upon the cardiovascular system, water balance, sodium balance, and ACTH-cortisol secretion.
本文首先简要介绍了肾素-血管紧张素系统（RAS）及其抑制剂和受体，以及脑内固有RAS的存在情况。然后，综述聚焦于室周器官，将其作为血源性血管紧张素II（Ang II）的脑内靶点，并探讨中枢介导的Ang II效应。这些效应涉及对心血管系统、水平衡、钠平衡以及促肾上腺皮质激素-皮质醇分泌的影响。
