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新奥斯汀：一种由青霉菌产生的半萜类化合物。

Neoaustin: a meroterpene produced by Penicillium sp.

作者信息

Zukerman-Schpector Julio, Maganhi Stella H, Fill Taicia Pacheco, Rodrigues-Fo Edson, Caracelli Ignez

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 25;65(Pt 3):o612. doi: 10.1107/S1600536809006618.

DOI:10.1107/S1600536809006618
PMID:21582264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968484/
Abstract

The title meroterpene neoaustin {systematic name: (1'S,2'R,3S,7'R,9'S,11'S,12'R)-11'-hydr-oxy-2,2,2',9',12'-penta-methyl-6',15'-dimethyl-ene-2,6-dihydro-13'-oxaspiro-[pyran-3,5'-tetra-cyclo-[7.5.1.0(1,11).0(2,7)]penta-deca-ne]-6,10',14'-trione}, C(25)H(30)O(6), comprises five rings, three six-membered and two five-membered. The absolute configuration was established based on [α(D)] = +166.91° (c 1.21, CH(2)Cl(2)). In the crystal, the mol-ecules are connected into a supra-molecular helical chain via O-H⋯O hydrogen bonds reinforced by C-H⋯O contacts.

摘要

标题化合物半萜新奥斯汀（系统命名：(1'S,2'R,3S,7'R,9'S,11'S,12'R)-11'-羟基-2,2,2',9',12'-五甲基-6',15'-亚甲基-2,6-二氢-13'-氧杂螺[吡喃-3,5'-四环[7.5.1.0(1,11).0(2,7)]十五烷]-6,10',14'-三酮），化学式为C(25)H(30)O(6)，由五个环组成，其中三个六元环和两个五元环。其绝对构型是根据[α(D)] = +166.91°（c 1.21，CH(2)Cl(2)）确定的。在晶体中，分子通过O-H⋯O氢键连接成超分子螺旋链，C-H⋯O接触增强了这种氢键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee1/2968484/3fd276d3e85f/e-65-0o612-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee1/2968484/0783362e2b29/e-65-0o612-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee1/2968484/3fd276d3e85f/e-65-0o612-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee1/2968484/0783362e2b29/e-65-0o612-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee1/2968484/3fd276d3e85f/e-65-0o612-fig2.jpg

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本文引用的文献

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Preaustinoid A: a meroterpene produced by Penicillium sp.
Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 8;65(Pt 2):o221. doi: 10.1107/S1600536808043481.
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