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2-溴-5,7-二甲氧基-4-苯基喹啉

2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline.

作者信息

Gopal Veshal, Bhadbhade Mohan, Chan Daniel Shiu Hin, Leu Chao-Wei, Black David Stc, Kumar Naresh

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 28;65(Pt 3):o635. doi: 10.1107/S160053680900587X.

DOI:10.1107/S160053680900587X
PMID:21582284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968525/
Abstract

The title compound, C(17)H(14)BrNO(2), was synthesized by the treatment of 5,7-dimeth-oxy-4-phenyl-quinolin-2-one with phosphoryl bromide in a Vilsmeier-type reaction. There are two independent mol-ecules (A and B) in the asymmetric unit which differ by 11.2° in the orientation of the 4-phenyl ring with respect to the planar quinoline ring system [dihedral angles = 55.15 (8) and 66.34 (8)° in mol-ecules A and B, respectively]. In the crystal structure, the independent mol-ecules are linked via C-H⋯N and C-H⋯O hydrogen bonds, forming centrosymmetric tetra-meric units which are cross-linked through C-H⋯π and C-Br⋯π inter-actions with Br⋯centroid distances of 3.4289 (8) and 3.5967 (8) Å.

摘要

标题化合物C(17)H(14)BrNO(2)是通过在Vilsmeier型反应中用磷酰溴处理5,7-二甲氧基-4-苯基喹啉-2-酮合成的。不对称单元中有两个独立分子（A和B），4-苯基环相对于平面喹啉环系统的取向相差11.2°[分子A和B中的二面角分别为55.15 (8)和66.34 (8)°]。在晶体结构中，独立分子通过C-H⋯N和C-H⋯O氢键相连，形成中心对称的四聚体单元，这些单元通过C-H⋯π和C-Br⋯π相互作用交联，Br⋯质心距离为3.4289 (8)和3.5967 (8) Å。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b000/2968525/77a4c1e391de/e-65-0o635-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b000/2968525/16d089a5cf25/e-65-0o635-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b000/2968525/77a4c1e391de/e-65-0o635-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b000/2968525/16d089a5cf25/e-65-0o635-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b000/2968525/77a4c1e391de/e-65-0o635-fig2.jpg

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本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
3-Aryl-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration.
J Med Chem. 2002 Jun 6;45(12):2543-55. doi: 10.1021/jm010978m.