• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（E）-6-氯-N'-（3,5-二氯-2-羟基-亚苄基）-烟酰肼

(E)-6-Chloro-N'-(3,5-dichloro-2-hydroxy-benzyl-idene)-nicotinohydrazide.

作者信息

Ren Chun-Yan

机构信息

College of Chemistry and Pharmacy, Qingdao Agricultural University, Shandong 266109, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 6;65(Pt 4):o678. doi: 10.1107/S1600536809007272.

DOI:10.1107/S1600536809007272
PMID:21582422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968879/
Abstract

The title Schiff base compound, C(13)H(8)Cl(3)N(3)O(2), was synthesized by the condensation reaction of 3,5-dichloro-salicyl-aldehyde with 6-chloro-nicotinic acid hydrazide in 95% ethanol. The mol-ecule is nearly planar, with a dihedral angle of 1.9 (2)° between the aromatic ring planes, and an intra-molecular O-H⋯N hydrogen bond is observed. In the crystal, the mol-ecules are connected by inter-molecular N-H⋯O hydrogen bonds into infinite chains propagating in [100].

摘要

席夫碱化合物C(13)H(8)Cl(3)N(3)O(2)是通过3,5-二氯水杨醛与6-氯烟酸酰肼在95%乙醇中发生缩合反应合成的。分子近乎平面，芳环平面之间的二面角为1.9 (2)°，并观察到分子内O-H⋯N氢键。在晶体中，分子通过分子间N-H⋯O氢键连接成在[100]方向传播的无限链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe73/2968879/fef665eddcb1/e-65-0o678-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe73/2968879/8ead03ca9671/e-65-0o678-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe73/2968879/fef665eddcb1/e-65-0o678-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe73/2968879/8ead03ca9671/e-65-0o678-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe73/2968879/fef665eddcb1/e-65-0o678-fig2.jpg

相似文献

1
(E)-6-Chloro-N'-(3,5-dichloro-2-hydroxy-benzyl-idene)-nicotinohydrazide.（E）-6-氯-N'-（3,5-二氯-2-羟基-亚苄基）-烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 6;65(Pt 4):o678. doi: 10.1107/S1600536809007272.
2
(E)-N'-(3,5-Dibromo-2-hydroxy-benzyl-idene)nicotinohydrazide.（E）-N'-（3,5-二溴-2-羟基-亚苄基）烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 20;66(Pt 3):o670. doi: 10.1107/S1600536810006276.
3
N'-(3,5-Dichloro-2-hy-droxy-benzyl-idene)-4-(dimethyl-amino)-benzohydrazide methanol monosolvate.N'-(3,5-二氯-2-羟基亚苄基)-4-(二甲基氨基)苯甲酰肼甲醇单溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o1042. doi: 10.1107/S1600536812010148. Epub 2012 Mar 10.
4
6-Chloro-N'-(2-hydr-oxy-1-naphthyl-methyl-ene)nicotinohydrazide.6-氯-N'-(2-羟基-1-萘基亚甲基)烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o150. doi: 10.1107/S1600536807063611.
5
N'-(3-Bromo-5-chloro-2-hydroxy-benzyl-idene)-2-methoxy-benzohydrazide.N'-(3-溴-5-氯-2-羟基-亚苄基)-2-甲氧基-苯甲酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o851. doi: 10.1107/S1600536809010198.
6
(E)-N'-(5-Chloro-2-hydroxy-benzyl-idene)-3,5-dihydroxy-benzohydrazide mono-hydrate.（E）-N'-（5-氯-2-羟基-亚苄基）-3,5-二羟基-苯甲酰肼一水合物
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 11;65(Pt 4):o721. doi: 10.1107/S1600536809007788.
7
N'-(3,5-Dichloro-2-hydroxy-benzyl-idene)-3-methoxy-benzohydrazide methanol solvate.N'-(3,5-二氯-2-羟基-亚苄基)-3-甲氧基-苯甲酰肼甲醇溶剂化物
Acta Crystallogr Sect E Struct Rep Online. 2008 Apr 30;64(Pt 5):o948. doi: 10.1107/S160053680801235X.
8
N'-(5-Chloro-2-hydroxy-benzyl-idene)nicotinohydrazide.N'-(5-氯-2-羟基-亚苄基)烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Jun 6;65(Pt 7):o1505-6. doi: 10.1107/S1600536809020819.
9
(E)-N'-(3-Bromo-5-chloro-2-hy-droxy-benzyl-idene)nicotinohydrazide.（E）-N'-（3-溴-5-氯-2-羟基亚苄基）烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2716. doi: 10.1107/S1600536811038268. Epub 2011 Sep 30.
10
N'-(5-Bromo-2-hydroxy-benzyl-idene)-4-chloro-benzohydrazide.N'-(5-溴-2-羟基-亚苄基)-4-氯苯甲酰肼
Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 6;66(Pt 4):o751. doi: 10.1107/S160053681000752X.

引用本文的文献

1
Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes.异烟肼与氟化苯甲醛衍生的席夫碱及其铜（II）配合物的抗菌活性和脲酶抑制作用
Molecules. 2016 Dec 17;21(12):1742. doi: 10.3390/molecules21121742.

本文引用的文献

1
6-Chloro-N'-(2-hydr-oxy-1-naphthyl-methyl-ene)nicotinohydrazide.6-氯-N'-(2-羟基-1-萘基亚甲基)烟酰肼
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 6;64(Pt 1):o150. doi: 10.1107/S1600536807063611.
2
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
3
A cobalt(III)-salen complex with an axial substituent in the diamine backbone: stereoselective recognition of amino alcohols.
J Am Chem Soc. 2005 Dec 7;127(48):16776-7. doi: 10.1021/ja0557785.
4
Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents.作为潜在抗肿瘤剂的新型羟基氨基脲席夫碱的合成、生物学评价及定量构效关系分析
J Med Chem. 2002 Jan 17;45(2):410-9. doi: 10.1021/jm010252q.