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N-[2,6-双（甲氧基甲氧基）苯基]亚氨基二乙酸二叔丁酯

Di-tert-butyl N-[2,6-bis-(methoxy-meth-oxy)phen-yl]imino-diacetate.

作者信息

Capuano Ben, Crosby Ian T, Forsyth Craig M, Khakham Yelena, Manallack David T

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o819. doi: 10.1107/S1600536809009246.

DOI:10.1107/S1600536809009246
PMID:21582540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2968827/
Abstract

The title mol-ecule, C(20)H(31)NO(8), has pseudo-C2 symmetry about the C-N bond, with the bis-(tert-butoxy-carbon-yl)amino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxy-carbonyl (Boc) groups are orientated away from the substituted aniline group. As part of an anti-bacterial drug discovery programme furnishing analogues of platensimycin, we unexpectedly synthesized the bis-Boc-protected aniline.

摘要

标题分子C(20)H(31)NO(8)关于C-N键具有伪C2对称性，双（叔丁氧羰基）氨基与苯环平面扭转约60°，且庞大的叔丁氧羰基（Boc）基团远离取代苯胺基。作为提供普拉特烯霉素类似物的抗菌药物发现计划的一部分，我们意外地合成了双Boc保护的苯胺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/2968827/d1219b1b005e/e-65-0o819-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/2968827/d1219b1b005e/e-65-0o819-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca1/2968827/d1219b1b005e/e-65-0o819-fig1.jpg

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本文引用的文献

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A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
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Total synthesis of platensimycin.普拉特烯霉素的全合成。
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