N-[2,6-双（甲氧基甲氧基）苯基]亚氨基二乙酸二叔丁酯
Di-tert-butyl N-[2,6-bis-(methoxy-meth-oxy)phen-yl]imino-diacetate.
作者信息
Capuano Ben, Crosby Ian T, Forsyth Craig M, Khakham Yelena, Manallack David T
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o819. doi: 10.1107/S1600536809009246.
Abstract
The title mol-ecule, C(20)H(31)NO(8), has pseudo-C2 symmetry about the C-N bond, with the bis-(tert-butoxy-carbon-yl)amino group twisted from the benzene ring plane by ca 60° and the bulky tert-butoxy-carbonyl (Boc) groups are orientated away from the substituted aniline group. As part of an anti-bacterial drug discovery programme furnishing analogues of platensimycin, we unexpectedly synthesized the bis-Boc-protected aniline.
摘要
标题分子C(20)H(31)NO(8)关于C-N键具有伪C2对称性，双（叔丁氧羰基）氨基与苯环平面扭转约60°，且庞大的叔丁氧羰基（Boc）基团远离取代苯胺基。作为提供普拉特烯霉素类似物的抗菌药物发现计划的一部分，我们意外地合成了双Boc保护的苯胺。
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