• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

3-（4-溴-苯基-磺酰基）-8-甲基-1,3-二氮杂螺[4.5]癸烷-2,4-二酮

3-(4-Bromo-phenyl-sulfon-yl)-8-methyl-1,3-diaza-spiro-[4.5]decane-2,4-dione.

作者信息

Kashif M Kalim, Khawar Rauf M, Bolte Michael, Hameed Shahid

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 18;65(Pt 8):o1892. doi: 10.1107/S1600536809027305.

DOI:10.1107/S1600536809027305
PMID:21583582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2977264/
Abstract

The crystal structure of the title compound, C(15)H(17)BrN(2)O(4)S, is stabilized by inter-molecular N-H⋯O hydrogen bonds which link the mol-ecules into centrosymmetric dimers. The dihedral angle subtended by the 4-bromo-phenyl group with the mean plane passing through the hydantoin unit is 83.29 (5)°. The cyclo-hexyl group adopts an ideal chair conformation with the methyl group in an equatorial position.

摘要

标题化合物C(15)H(17)BrN(2)O(4)S的晶体结构通过分子间N-H⋯O氢键得以稳定，这些氢键将分子连接成中心对称的二聚体。4-溴苯基与通过乙内酰脲单元的平均平面所成的二面角为83.29 (5)°。环己基呈理想的椅式构象，甲基处于平伏位置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6694/2977264/540c9b7f84c0/e-65-o1892-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6694/2977264/540c9b7f84c0/e-65-o1892-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6694/2977264/540c9b7f84c0/e-65-o1892-fig1.jpg

相似文献

1
3-(4-Bromo-phenyl-sulfon-yl)-8-methyl-1,3-diaza-spiro-[4.5]decane-2,4-dione.3-（4-溴-苯基-磺酰基）-8-甲基-1,3-二氮杂螺[4.5]癸烷-2,4-二酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 18;65(Pt 8):o1892. doi: 10.1107/S1600536809027305.
2
3-(4-Chloro-phenyl-sulfon-yl)-8-methyl-1,3-diaza-spiro-[4.5]decane-2,4-dione.3-（4-氯-苯基-磺酰基）-8-甲基-1,3-二氮杂螺[4.5]癸烷-2,4-二酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 18;65(Pt 8):o1893. doi: 10.1107/S1600536809027482.
3
3-(4-Bromo-phenyl-sulfon-yl)-5-cyclo-hexyl-2-methyl-1-benzofuran.3-（4-溴-苯基-磺酰基）-5-环己基-2-甲基-1-苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o480. doi: 10.1107/S1600536812001791. Epub 2012 Jan 21.
4
3-(2-Bromo-phenyl-sulfon-yl)-5-cyclo-hexyl-2-methyl-1-benzo-furan.3 - （2 - 溴苯基磺酰基）- 5 - 环己基 - 2 - 甲基 - 1 - 苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 22;70(Pt 3):o324. doi: 10.1107/S1600536814003547. eCollection 2014 Mar 1.
5
Crystal structures of three N-(aryl-sulfon-yl)-4-fluoro-benzamides.三种N-（芳基磺酰基）-4-氟苯甲酰胺的晶体结构
Acta Crystallogr E Crystallogr Commun. 2016 Mar 31;72(Pt 4):575-82. doi: 10.1107/S2056989016005089. eCollection 2016 Apr 1.
6
5-Cyclo-hexyl-3-(3-fluoro-phenyl-sulfon-yl)-2-methyl-1-benzofuran.5-环己基-3-(3-氟苯基磺酰基)-2-甲基-1-苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1053. doi: 10.1107/S1600536811011767. Epub 2011 Apr 7.
7
5-Cyclo-hexyl-3-(4-fluoro-phenyl-sulfon-yl)-2-methyl-1-benzofuran.5-环己基-3-(4-氟苯基磺酰基)-2-甲基-1-苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o767. doi: 10.1107/S1600536811006593. Epub 2011 Mar 2.
8
5-Cyclo-hexyl-2-methyl-3-(4-methyl-phenyl-sulfon-yl)-1-benzofuran.5-环己基-2-甲基-3-(4-甲基苯基磺酰基)-1-苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o1068. doi: 10.1107/S1600536812010434. Epub 2012 Mar 14.
9
Crystal structure of (5'S,8'S)-3-(2,5-di-methyl-phen-yl)-8-meth-oxy-3-nitro-1-aza-spiro-[4.5]decane-2,4-dione.(5'S,8'S)-3-(2,5-二甲基苯基)-8-甲氧基-3-硝基-1-氮杂螺[4.5]癸烷-2,4-二酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Mar 14;71(Pt 4):o238-9. doi: 10.1107/S2056989015004715. eCollection 2015 Apr 1.
10
3-(4-Bromo-phenyl-sulfon-yl)-5-cyclo-pentyl-2-methyl-1-benzofuran.3-（4-溴-苯基-磺酰基）-5-环戊基-2-甲基-1-苯并呋喃
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1624. doi: 10.1107/S1600536812019411. Epub 2012 May 5.

本文引用的文献

1
1-(4-Methoxy-phenyl-sulfon-yl)-5-methyl-5-phenyl-imidazolidine-2,4-dione.1-（4-甲氧基-苯基-磺酰基）-5-甲基-5-苯基-咪唑烷-2,4-二酮
Acta Crystallogr Sect E Struct Rep Online. 2009 May 7;65(Pt 6):o1207-8. doi: 10.1107/S1600536809016092.
2
1-(4-Chloro-phenyl-sulfon-yl)-5-(4-fluoro-phen-yl)-5-methyl-imidazolidine-2,4-dione.1-（4-氯-苯基-磺酰基）-5-（4-氟-苯基）-5-甲基-咪唑烷-2,4-二酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o858-9. doi: 10.1107/S160053680901037X.
3
5-(4-Fluoro-phen-yl)-5-methyl-imidazolidine-2,4-dione.
5-（4-氟苯基）-5-甲基咪唑烷-2,4-二酮
Acta Crystallogr Sect E Struct Rep Online. 2008 Jan 16;64(Pt 2):o444. doi: 10.1107/S1600536807067803.
4
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
5
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
6
Pharmacologic therapy for type 2 diabetes mellitus.2型糖尿病的药物治疗
Ann Intern Med. 1999 Aug 17;131(4):281-303. doi: 10.7326/0003-4819-131-4-199908170-00008.
7
Treatment of type 2 diabetes mellitus.2型糖尿病的治疗
Med Clin North Am. 1998 Jul;82(4):757-90. doi: 10.1016/s0025-7125(05)70023-7.
8
Effects of 1-(3-bromobenzofuran-2-ylsulfonyl)hydantoin on human aldose reductase examined by a new application of HPLC system for measuring tissue polyol.通过用于测量组织多元醇的高效液相色谱系统的新应用检测1-(3-溴苯并呋喃-2-基磺酰基)乙内酰脲对人醛糖还原酶的影响。
Arzneimittelforschung. 1997 Nov;47(11):1222-5.
9
Two cyclohexanespiro-5'-hydantoin monohydrates.两种环己烷螺-5'-乙内酰脲一水合物。
Acta Crystallogr C. 1997 Nov 15;53 ( Pt 11):1659-61. doi: 10.1107/s0108270197007488.
10
An empirical correction for absorption anisotropy.吸收各向异性的经验校正
Acta Crystallogr A. 1995 Jan 1;51 ( Pt 1):33-8. doi: 10.1107/s0108767394005726.