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5-（4-溴苯基）-1,2,3,4-四氢苯并[a]菲啶

5-(4-Bromo-phen-yl)-1,2,3,4-tetra-hydro-benzo[a]phenanthridine.

作者信息

Xie Heng-Shen, Zhang Ai-Ling, Su Ling

机构信息

Division of Science and Technology, Xuzhou Institute of Architectural Technology, Xuzhou 221116, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65(Pt 5):o1074. doi: 10.1107/S1600536809013713.

DOI:10.1107/S1600536809013713
PMID:21583889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2977753/
Abstract

The title compound, C(23)H(18)BrN, was synthesized by the reaction of 4-bromo-benzaldehyde, naphthalen-2-amine and cyclo-hexa-none in tetra-hydro-furan, catalyzed by iodine. The saturated six-membered ring adopts a half-chair conformation, and the four vicinal rings form a helical conformation, which results in a significant deviation from planarity for the pyridine ring. In the crystal, a weak C-H⋯π inter-action occurs, leading to inversion dimers.

摘要

标题化合物C(23)H(18)BrN是由4-溴苯甲醛、萘-2-胺和环己酮在四氢呋喃中于碘催化下反应合成的。饱和六元环呈半椅式构象，四个相邻环形成螺旋构象，这导致吡啶环显著偏离平面性。在晶体中，存在弱的C-H⋯π相互作用，形成反演二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/2977753/2c23bf01b191/e-65-o1074-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/2977753/de85d1820f47/e-65-o1074-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/2977753/2c23bf01b191/e-65-o1074-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/2977753/de85d1820f47/e-65-o1074-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/2977753/2c23bf01b191/e-65-o1074-fig2.jpg

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1
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J Med Chem. 2005 Apr 21;48(8):2772-7. doi: 10.1021/jm0490888.
3
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5
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Angew Chem Int Ed Engl. 2005 Jan 14;44(4):635-8. doi: 10.1002/anie.200461969.
6
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