Yeger H, Mor O, Pawlin G, Kaplinsky C, Shiloh Y
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Cancer Res. 1990 May 1;50(9):2794-802.
A neuroblastic-like cell line (NUB-20) was derived from a case of histopathologically diagnosed metastatic neuroblastoma. The metastatic tumor and nude mouse heterotransplant resembled neuroblastoma by histological criteria, in contrast to the primary tumor, which was differentially classified as Ewing's sarcoma. However, the cell line demonstrated a unique phenotype in culture with respect to morphology, immunohistochemical markers, and sensitivity to a battery of differentiation modulators. These characteristics, together with the presence of a chromosomal translocation (11;22),(q24;q12) and amplification with enhanced expression of the c-myc protooncogene rather than N-myc, established this tumor as neuroepithelioma. Neuroepithelioma is a tumor type distinct from, but related to, neuroblastoma in its development from the neural crest lineage. These results emphasize the growing importance of cytogenetic and molecular markers in the classification and characterization of human tumors.
一种神经母细胞瘤样细胞系（NUB - 20）源自一例经组织病理学诊断为转移性神经母细胞瘤的病例。与被鉴别分类为尤因肉瘤的原发性肿瘤不同，转移性肿瘤和裸鼠异种移植瘤根据组织学标准类似于神经母细胞瘤。然而，该细胞系在培养中表现出独特的表型，涉及形态学、免疫组化标志物以及对一系列分化调节剂的敏感性。这些特征，连同存在染色体易位（11；22），（q24；q12）以及c - myc原癌基因而非N - myc的扩增和表达增强，将该肿瘤确定为神经上皮瘤。神经上皮瘤是一种在发育上源于神经嵴谱系、与神经母细胞瘤不同但相关的肿瘤类型。这些结果强调了细胞遗传学和分子标志物在人类肿瘤分类和特征描述中日益增长的重要性。
