Vieira Neto Leonardo, Abucham Julio, Araujo Luiz Antônio de, Boguszewski Cesar L, Bronstein Marcello D, Czepielewski Mauro, Jallad Raquel S, Musolino Nina R de C, Naves Luciana A, Ribeiro-Oliveira Júnior Antônio, Vilar Lucio, Faria Manuel Dos S, Gadelha Mônica R
Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.
Arq Bras Endocrinol Metabol. 2011 Mar;55(2):91-105. doi: 10.1590/S0004-27302011000200001.
Acromegaly is a disease associated with increased morbidity and reduced life expectancy. Because of its insidious character and its non-recognition, the diagnosis is often made with delay, which, along with the complications related to GH/IGF-I excess, determines high morbidity and mortality. However, an early diagnosis and an effective treatment reduce the morbidity and normalize the mortality rate. In this publication, the goal of Neuroendocrinology Department from Brazilian Society of Endocrinology and Metabolism is to disclose which clinical set should arouse the suspicious of acromegaly and how to diagnose it. Furthermore, we discuss the most effective and safe approach to perform the treatment of acromegaly, emphasizing that it must be carried out in reference centers. Therefore, based on data published in journals with recognized scientific level and authors' experience, recommendations are presented for diagnosis and treatment of the disease.
肢端肥大症是一种与发病率增加和预期寿命缩短相关的疾病。由于其隐匿性和未被识别，诊断往往延迟，这与生长激素/胰岛素样生长因子-1过量相关的并发症一起，导致高发病率和死亡率。然而，早期诊断和有效治疗可降低发病率并使死亡率正常化。在本出版物中，巴西内分泌与代谢学会神经内分泌科的目标是揭示哪些临床情况应引起对肢端肥大症的怀疑以及如何进行诊断。此外，我们讨论了治疗肢端肥大症最有效和安全的方法，强调必须在参考中心进行。因此，基于发表在具有公认科学水平的期刊上的数据和作者的经验，提出了该疾病的诊断和治疗建议。
