Panveloski-Costa Ana Carolina, Pinto Júnior Danilo Antônio Correa, Brandão Bruna Brasil, Moreira Rafael Junges, Machado Ubiratan Fabres, Seraphim Patrícia Monteiro
Departamento de Fisioterapia, Universidade Estadual Paulista Júlio de Mesquita Filho, Presidente Prudente, SP, Brasil.
Arq Bras Endocrinol Metabol. 2011 Mar;55(2):155-63. doi: 10.1590/S0004-27302011000200008.
To determine if resistive exercise protocol can modulate Tnf-α, SOCS3 and glucose transporter GLUT4 genes expression in skeletal muscle, and peripheral insulin sensitivity in obese rats induced by hyperlipidic diet.
Wistar obese rats induced by hyperlipidic diet were subjected a resistive exercise protocol as jump squat. Insulin sensitivity and mRNA content of Tnf-α, SOCS3 and GLUT4 were assayed and compared among the groups: obese sedentary (OS) and exercised (OE), control sedentary (CS) and exercised (CE).
The mRNA content of Tnf-α and SOCS3 has increased in skeletal muscle from OS and has decreased in OE group. The protein and GLUT4 mRNA contents were correlated but they did not change among the groups. Peripheral insulin sensitivity has increased in the OE compared to OS group.
The resistive exercise reverses the peripheral insulin resistance and the inflammatory state in skeletal muscle from diet-induced obese rats.
