Gonos E, Powell A, Jat P
LUDWIG INST CANC RES,COURTAULD BLDG,91 RIDING HOUSE ST,LONDON W1P 8BT,ENGLAND.
Int J Oncol. 1992 Jul;1(2):209-13.
Normal mammalian fibroblasts cultured in vitro will not divide indefinitely but undergo senescence and give rise to cells that can no longer be induced to divide. It is possible to overcome this finite life span by either cellular mutation or by the exogenous introduction of some viral or cellular oncogenes. This review describes the characteristics of senescence and the different ways in which it can be overcome.
体外培养的正常哺乳动物成纤维细胞不会无限分裂，而是会经历衰老，并产生无法再被诱导分裂的细胞。通过细胞突变或外源性引入某些病毒或细胞癌基因，可以克服这种有限的寿命。本综述描述了衰老的特征以及克服衰老的不同方法。
