Department of Food and Nutritional Sciences, Hanbuk University, Dongducheon, 483-120, South Korea.
Biol Trace Elem Res. 2011 Dec;144(1-3):992-1002. doi: 10.1007/s12011-011-9073-2. Epub 2011 May 17.
Commercially available seaweed calcium extract can supply high amounts of calcium as well as significant amounts of magnesium and other microminerals. The purpose of this study was to investigate the degree to which the high levels of magnesium in seaweed calcium extract affects the calcium balance and the bone status in ovariectomized rats in comparison to rats supplemented with calcium carbonate and magnesium oxide. A total of 40 Sprague-Dawley female rats (7 weeks) were divided into four groups and bred for 12 weeks: sham-operated group (Sham), ovariectomized group (OVX), ovariectomized with inorganic calcium and magnesium supplementation group (OVX-Mg), and ovariectomized with seaweed calcium and magnesium supplementation group (OVX-SCa). All experimental diets contained 0.5% calcium. The magnesium content in the experimental diet was 0.05% of the diet in the Sham and OVX groups and 0.1% of the diet in the OVX-Mg and OVX-SCa groups. In the calcium balance study, the OVX-Mg and OVX-SCa groups were not significantly different in calcium absorption compared to the OVX group. However, the femoral bone mineral density and strength of the OVX-SCa group were higher than those of the OVX-Mg and OVX groups. Seaweed calcium with magnesium supplementation or magnesium supplementation alone did not affect the serum ALP and CTx levels in ovariectomized rats. In summary, consumption of seaweed calcium extract or inorganic calcium carbonate with magnesium oxide demonstrated the same degree of intestinal calcium absorption, but only the consumption of seaweed calcium extract resulted in increased femoral bone mineral density and strength in ovariectomized rats. Our results suggest that seaweed calcium extract is an effective calcium and magnesium source for improving bone health compared to synthetic calcium and magnesium supplementation.
市售海藻钙提取物可提供大量的钙以及大量的镁和其他微量元素。本研究旨在研究海藻钙提取物中高水平的镁对去卵巢大鼠钙平衡和骨状况的影响，并与碳酸钙和氧化镁补充的大鼠进行比较。共 40 只 Sprague-Dawley 雌性大鼠（7 周龄）分为 4 组，繁殖 12 周：假手术组（Sham）、去卵巢组（OVX）、去卵巢加无机钙和镁补充组（OVX-Mg）和去卵巢加海藻钙和镁补充组（OVX-SCa）。所有实验饮食均含有 0.5%的钙。实验饮食中的镁含量在 Sham 和 OVX 组为饮食的 0.05%，在 OVX-Mg 和 OVX-SCa 组为饮食的 0.1%。在钙平衡研究中，与 OVX 组相比，OVX-Mg 和 OVX-SCa 组的钙吸收率没有显著差异。然而，OVX-SCa 组的股骨骨密度和强度高于 OVX-Mg 和 OVX 组。海藻钙与镁补充或单独补充镁对去卵巢大鼠的血清 ALP 和 CTx 水平没有影响。总之，食用海藻钙提取物或无机碳酸钙与氧化镁具有相同程度的肠道钙吸收，但只有食用海藻钙提取物可使去卵巢大鼠的股骨骨密度和强度增加。我们的结果表明，与合成钙和镁补充相比，海藻钙提取物是一种有效的钙和镁来源，可改善骨骼健康。
