Koo Ja Seung, Park Seho, Kim Seung Il, Lee Sarah, Park Byeong-Woo
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Tumour Biol. 2011 Aug;32(4):787-99. doi: 10.1007/s13277-011-0181-6. Epub 2011 May 17.
We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.
我们旨在通过免疫组织化学研究小窝蛋白-1、-2、-3和血小板衍生生长因子（PDGF）β受体在乳腺癌细胞和基质中的表达，并分析其意义。随着肿瘤从原位导管癌发展为微浸润性导管癌、浸润性导管癌（IDC）的导管内成分以及IDC，基质中小窝蛋白-2和PDGFβ受体的表达率升高（p<0.001）。IDC肿瘤基质中小窝蛋白-1的表达缺失与高肿瘤分期（p<0.001）、高淋巴结分期（p=0.011）、高癌症分期（p=0.005）、雌激素受体阴性（p=0.003）以及肿瘤复发（p=0.003）相关。此外，肿瘤基质中小窝蛋白-1的表达缺失与无病生存期缩短和总生存期缩短相关（p<0.001）。总之，基质中小窝蛋白-1的缺失与IDC的不良预后相关。
