体内 γδ T 细胞与其相邻细胞相互作用的动力学。
Dynamics of the interaction of γδ T cells with their neighbors in vivo.
机构信息
Institute of Immunology, Hannover Medical School, 30625, Hannover, Germany, Prinz.
出版信息
Cell Mol Life Sci. 2011 Jul;68(14):2391-8. doi: 10.1007/s00018-011-0701-y. Epub 2011 May 17.
Abstract
γδ T cells are a diverse component of the immune system in humans and mice with presumably important but still largely unknown functions. Understanding the dynamic interaction of γδ T cells with their neighbors should help to understand their physiological role. This review addresses recent advances and strategies to visualize the dynamic interactions of γδ T cells with their neighbors in vivo. Current knowledge regarding the dynamic contacts of tissue resident γδ T cells and epithelial cells, but also of the communication between circulating γδ T cells and DCs, monocytes and FoxP3(+) regulatory T cells is revisited with emphasis on the role of γδ T cell motility.
摘要
γδ T 细胞是人类和小鼠免疫系统中的一个多样化组成部分，具有推测上的重要但仍在很大程度上未知的功能。了解 γδ T 细胞与其相邻细胞的动态相互作用应该有助于理解其生理作用。本综述讨论了在体内可视化 γδ T 细胞与其相邻细胞的动态相互作用的最新进展和策略。本文重新审视了组织驻留 γδ T 细胞与上皮细胞之间的动态接触，以及循环 γδ T 细胞与 DCs、单核细胞和 FoxP3(+)调节性 T 细胞之间的通讯，重点介绍了 γδ T 细胞迁移的作用。
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