Hernández-Vargas René, Fonseca-Ornelas Luis, López-González Ignacio, Riesgo-Escovar Juan, Zurita Mario, Reynaud Enrique
Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.
Genesis. 2011 May;49(5):392-402. doi: 10.1002/dvg.20740.
Parkinson's disease (PD) is the second most common neurodegenerative disorder in humans. It affects 1% of the population over 65-years old. Its causes are environmental and genetic. As the world population ages, there is an urgent need for better and more detailed animal models for this kind of disease. In this work we show that the use of transgenic Drosophila is comparable to more complicated and costly animal models such as mice. The Drosophila model behaves very similar to the equivalent transgenic mice model. We show that both Synphilin-1 and α-synuclein are toxic by themselves, but when co-expressed, they suppress their toxicity reciprocally. Importantly, the symptoms induced in the fly can be treated and partially reverted using standard PD pharmacological treatments. This work showcases Drosophila as a detailed and multifaceted model for Parkinson's disease, providing a convenient platform in which to study and find new genetic modifiers of PD. genesis 49:392-402, 2011.
帕金森病（PD）是人类第二常见的神经退行性疾病。它影响1%的65岁以上人群。其病因包括环境因素和遗传因素。随着世界人口老龄化，迫切需要针对这类疾病的更好、更详细的动物模型。在这项工作中，我们表明，使用转基因果蝇与使用诸如小鼠等更复杂且成本更高的动物模型具有可比性。果蝇模型的行为与等效的转基因小鼠模型非常相似。我们表明，Synphilin-1和α-突触核蛋白本身都具有毒性，但当它们共表达时，会相互抑制对方的毒性。重要的是，果蝇中诱导出的症状可以通过标准的帕金森病药物治疗进行治疗并部分逆转。这项工作展示了果蝇作为帕金森病的详细且多方面的模型，为研究和发现帕金森病新的基因修饰因子提供了一个便利的平台。《发生学》49:392 - 402，2011年。
