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一种结合光疗和热疗方法的新型痤疮治疗设备的特性研究。

Characterization of a new acne vulgaris treatment device combining light and thermal treatment methods.

机构信息

Department of Biomedical Engineering, Yonsei University, Wonju, Korea.

出版信息

Skin Res Technol. 2012 Feb;18(1):15-21. doi: 10.1111/j.1600-0846.2011.00540.x. Epub 2011 May 18.

Abstract

BACKGROUND/PURPOSE: Conventional treatment methods for acne vulgaris have various side effects such as the development of bacterial resistance, phototoxicity, vertigo, gastro-intestinal problems, and drug eruptions. To minimize such side effects, light and thermal methods have been alternately suggested. This study characterized a new acne vulgaris treatment device (AVTD) that combines both light and thermal methods and evaluated its clinical efficacy.

METHODS

We characterized the thermal and light properties of the AVTD itself and evaluated its thermal characteristics in ex vivo porcine skin samples. The Arrhenius equation was used to calculate the skin thermal injury coefficient to confirm the skin safety of the AVTD. Finally, the clinical efficacy of the AVDT was evaluated by analyzing cross-polarization and erythema index images, which were obtained from 13 volunteers undergoing treatment with the AVTD.

RESULTS

The temperature of the AVTD itself was maintained at 49.1 °C on the tip and 39.7 °C in the porcine skin samples. The peak intensity of the light-emitting diode (LED) light was observed at 468 nm. The skin safety of the AVTD was confirmed and 84.2% of the volunteers presented positive treatment results.

CONCLUSION

The treatment of acne using the AVTD resulted in a high treatment rate in a clinical study, minimizing side effects. On the basis of these results, we can be sure that the AVTD may be effectively used for the treatment of acne vulgaris.

摘要

背景/目的:痤疮的传统治疗方法存在多种副作用,如细菌耐药性的发展、光毒性、眩晕、胃肠问题和药物疹等。为了最大限度地减少这些副作用,交替提出了光和热方法。本研究对一种结合光和热方法的新型痤疮治疗设备(AVTD)进行了特征描述,并评估了其临床疗效。

方法

我们对 AVTD 本身的热和光特性进行了特征描述,并在离体猪皮样本中评估了其热特性。使用阿仑尼乌斯方程计算皮肤热损伤系数,以确认 AVTD 的皮肤安全性。最后,通过分析接受 AVTD 治疗的 13 名志愿者的交叉偏振和红斑指数图像,评估了 AVTD 的临床疗效。

结果

AVTD 本身的温度在尖端处保持在 49.1°C,在猪皮样本中保持在 39.7°C。发光二极管(LED)光的峰值强度出现在 468nm。AVTD 的皮肤安全性得到了确认,84.2%的志愿者的治疗结果为阳性。

结论

在一项临床研究中,使用 AVTD 治疗痤疮的结果显示出较高的治疗率,副作用最小。基于这些结果,我们可以肯定 AVTD 可能有效地用于治疗痤疮。

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