Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines.
作者信息
Kelley J L, Linn J A, Selway J W
机构信息
Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
出版信息
J Med Chem. 1990 May;33(5):1360-3. doi: 10.1021/jm00167a012.
PMID:2158561
Abstract
A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.
摘要
Zotero 插件