小核糖核酸病毒抑制剂
Picornavirus inhibitors.
作者信息
Carrasco L
机构信息
Centro de Biologia Molecular, Universidad Autonoma, Madrid, Spain.
出版信息
Pharmacol Ther. 1994;64(2):215-90. doi: 10.1016/0163-7258(94)90040-x.
Abstract
Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerous compounds that have been reported as inhibitors of picornavirus functions are reviewed. The picornavirus particles and several agents that interact with them have been solved at atomic resolution, leading to computer-assisted drug design. Picornavirus inhibitors are useful in aiding a better understanding of picornavirus biology. In addition, some of them are promising therapeutic agents. Clinical efficacy of agents that bind to picornavirus particles has already been demonstrated.
摘要
从分子层面来看，小核糖核酸病毒是了解最为透彻的动物病毒之一。许多重要的人类和动物病原体都是小核糖核酸病毒科的成员。本文综述了小核糖核酸病毒的基因组结构、其生长的不同阶段以及众多被报道为小核糖核酸病毒功能抑制剂的化合物。小核糖核酸病毒颗粒以及一些与其相互作用的因子已在原子分辨率下得到解析，从而推动了计算机辅助药物设计。小核糖核酸病毒抑制剂有助于更好地理解小核糖核酸病毒生物学。此外，其中一些还是很有前景的治疗药物。与小核糖核酸病毒颗粒结合的药物的临床疗效已经得到证实。
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