Strittmatter S M, Valenzuela D, Kennedy T E, Neer E J, Fishman M C
Developmental Biology Laboratory, Massachusetts General Hospital, Boston.
Nature. 1990 Apr 26;344(6269):836-41. doi: 10.1038/344836a0.
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.
G0是一种能从跨膜受体转导信息的GTP结合蛋白，已被发现是神经元生长锥膜的主要成分。GAP - 43是一种与神经元生长密切相关的细胞内生长锥蛋白，它能刺激GTP - γ - S与G0结合。它通过与G - 连接跨膜受体同源的氨基末端结构域来实现这一点。因此，生长锥中的G0可能受细胞内以及细胞外信号的调控。
