Fishman M C
Perspect Dev Neurobiol. 1996;4(2-3):193-8.
The brain must balance the need for synaptic precision with the ability to generate and change connectivity patterns in response to environmental stimuli. GAP-43 is a phosphoprotein associated with the cytosolic surface of the membrane, and is one of the most abundant among the small subset of total cellular proteins transported to the growth cone. It appears to play an unusual role amplifying signals from the microenvironment. One of the several ways to perform this task involves interaction of GAP-43 with the G protein transduction cascade. In mice rendered GAP-43 null by homologous recombination, some nerves manifest aberrant growth at decision points, such as the optic chiasm. Thus, GAP-43 may work via modulation of signaling cascades, rather than autonomously causing growth, and could serve to keep plasticity within constraints needed to generate and maintain accurate synaptic wiring.
大脑必须在对突触精确性的需求与响应环境刺激而生成和改变连接模式的能力之间取得平衡。GAP - 43是一种与膜的胞质表面相关的磷蛋白，是转运至生长锥的全部细胞蛋白的小亚群中最丰富的蛋白之一。它似乎在放大来自微环境的信号方面发挥着不同寻常的作用。执行此任务的几种方式之一涉及GAP - 43与G蛋白转导级联的相互作用。在通过同源重组使GAP - 43缺失的小鼠中，一些神经在决策点（如视交叉）表现出异常生长。因此，GAP - 43可能通过调节信号级联起作用，而不是自主地导致生长，并且可以在生成和维持精确突触连接所需的限制范围内保持可塑性。
