Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.
Br Med Bull. 2011;98:21-30. doi: 10.1093/bmb/ldr008. Epub 2011 May 17.
The crisis in organ availability has triggered innovative approaches to meet a rapidly expanding worldwide demand for donor kidneys. HLA and ABO incompatibility represents one of the most significant barriers to optimizing the utilization of living donors. Kidney paired donation (KPD) allows patients with incompatible live donors to receive compatible or better-matched organs by exchanging donors.
The data presented in this review have been published and represent the most up-to-date sources of the theory and practice of KPD.
There is wide agreement that in most cases the best transplant solution for a patient with an incompatible donor is to receive a compatible organ in a KPD.
There has been disagreement about the capacity of KPD to solve the incompatibility problem. However, it is now clear that not all phenotypes will benefit from KPD.
Combining KPD with desensitization greatly expands the boundaries of each of these modalities.
器官来源短缺的危机促使人们采取创新方法，以满足全球对供体肾脏不断增长的需求。HLA 和 ABO 不相容是优化活体供者利用的最大障碍之一。配对供肾（KPD）允许与活体供者不相容的患者通过供者交换来接受相容或更好匹配的器官。
本综述中介绍的数据已经发表，代表了 KPD 的理论和实践的最新资料来源。
大多数情况下，与活体供者不相容的患者的最佳移植解决方案是接受 KPD 中的相容器官。
关于 KPD 解决不相容问题的能力存在分歧。然而，现在很明显，并非所有表型都将受益于 KPD。
将 KPD 与脱敏相结合，极大地扩展了这两种方式的界限。
