Department of Ophthalmology, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.
Indian J Ophthalmol. 2011 May-Jun;59(3):201-5. doi: 10.4103/0301-4738.81027.
Pupil cycle time (PCT) has been widely used for examination of ocular diabetic autonomic neuropathy (DAN).
The primary aim of this study was to evaluate the difference of contrast sensitivity according to PCT results, and the secondary aim was to determine the factors associated with PCT difference for type II diabetes patients.
A clinical pilot study that included a total of 60 eyes of 60 type II diabetes patients.
We divided all patients into three groups according to PCT results. Group A and Group C were composed of patients who had upper one third PCT and lower one third PCT, respectively. We analyzed difference of age, diabetes duration, hypertension duration, mean best corrected visual acuity (BCVA), mean spherical equivalent (SE), HbA1C, glomerular filtration rate (GFR), stage of diabetic retinopathy, and Cardiac Autonomic Function Score (CAFS). Contrast sensitivity and decrease of visual acuity by glare were also estimated and analyzed for 28 eyes of 28 non-proliferative diabetic retinopathy (NPDR) patients. Group [NPDR] A and Group [NPDR] C were defined as those who had lower one third PCT and upper one third PCT, respectively.
Statistical analysis was done using SPSS 17.0 software.
Each group contained 20 eyes. Significant differences between Group A and Group C were observed in duration of diabetes and CAFS (P ≤ 0.001 and P < 0.001, respectively). Contrast sensitivity in Group [NPDR] A was significantly more than in Group [NPDR] C at all cpds (all P ≤ 0.001). We found that PCT can influence contrast sensitivity or glare in diabetes patients and also confirmed a significant correlation of PCT with CAFS and duration of diabetes.
瞳孔循环时间（PCT）已广泛用于检查眼部糖尿病自主神经病变（DAN）。
本研究的主要目的是评估根据 PCT 结果得出的对比敏感度差异，次要目的是确定与 II 型糖尿病患者 PCT 差异相关的因素。
一项共纳入 60 例 60 只眼的 II 型糖尿病患者的临床试点研究。
我们根据 PCT 结果将所有患者分为三组。A 组和 C 组分别由 PCT 上三分之一和下三分之一的患者组成。我们分析了年龄、糖尿病病程、高血压病程、最佳矫正视力（BCVA）平均值、平均球镜等效值（SE）、HbA1C、肾小球滤过率（GFR）、糖尿病视网膜病变分期和心脏自主神经功能评分（CAFS）的差异。还对 28 例非增生性糖尿病视网膜病变（NPDR）患者的 28 只眼进行了对比敏感度和眩光致视力下降的评估和分析。将下三分之一 PCT 和上三分之一 PCT 的患者分别定义为 Group [NPDR] A 和 Group [NPDR] C。
使用 SPSS 17.0 软件进行统计分析。
每组包含 20 只眼。A 组和 C 组之间在糖尿病病程和 CAFS 方面存在显著差异（P ≤ 0.001 和 P < 0.001）。Group [NPDR] A 的对比敏感度在所有 cpds 均显著高于 Group [NPDR] C（均 P ≤ 0.001）。我们发现 PCT 可影响糖尿病患者的对比敏感度或眩光，还证实了 PCT 与 CAFS 和糖尿病病程之间存在显著相关性。
