甲型肝炎疫苗在乳糜泻患儿中的免疫原性。

Immunogenicity of hepatitis A vaccine in children with celiac disease.

机构信息

Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.

出版信息

J Pediatr Gastroenterol Nutr. 2011 Nov;53(5):532-5. doi: 10.1097/MPG.0b013e318223b3ed.

DOI:10.1097/MPG.0b013e318223b3ed

PMID:21587080

Abstract

OBJECTIVES

The response to hepatitis A vaccine has not been studied in children with celiac disease (CD). The aim of the present study was to evaluate the immunogenicity of an inactivated hepatitis A virus (HAV) vaccine and the effect of the human leukocyte antigen (HLA) type on immunogenicity in children with CD.

PATIENTS AND METHODS

Thirty-three patients with CD and 62 healthy controls were enrolled in the study. Inactivated HAV vaccine (Havrix; GlaxoSmithKline Biologicals, Rixensart, Belgium) containing 720 enzyme-linked immunosorbent assay units of alum-adsorbed hepatitis A antigen was administered intramuscularly in a 2-dose schedule at 0 and 6 months. Seroconversion rates and antibody titers of HAV were measured at 1 and 7 months.

RESULTS

At 1 month, seroconversion rates were 78.8% and 77.4% and geometric mean titers were 50.7 and 49.9 mIU/mL in the CD and control groups, respectively (P > 0.05). At 7 months, seroconversion rates were 97% and 98.4% and geometric mean titers were 138.5 and 133 mIU/mL in the CD and control groups, respectively (P > 0.05). The most frequent HLA types were HLA-DQ2, -DR3, and -DR7 alleles in patients with CD and HLA-DQ3, -DQ6, -DR11, and -DR14 in the controls. There was no association between HLA alleles and antibody titers of hepatitis A vaccine.

CONCLUSION

Children with CD have a good immune response to hepatitis A vaccine, similar to healthy controls.

摘要

目的

尚未研究乳糜泻（CD）儿童对甲型肝炎疫苗的反应。本研究旨在评估灭活甲型肝炎病毒（HAV）疫苗的免疫原性以及人类白细胞抗原（HLA）类型对 CD 儿童免疫原性的影响。

患者和方法

本研究纳入了 33 名 CD 患儿和 62 名健康对照者。采用肌内注射的方式，以 0 和 6 个月为间隔，为患儿和对照者接种 2 剂含 720 酶联免疫吸附测定单位的铝吸附甲型肝炎抗原的灭活 HAV 疫苗（Havrix；葛兰素史克生物制品公司，比利时里克斯桑特）。于 1 个月和 7 个月时测量 HAV 的血清转化率和抗体滴度。

结果

1 个月时，CD 组和对照组的血清转化率分别为 78.8%和 77.4%，几何平均滴度分别为 50.7 和 49.9 mIU/mL（P＞0.05）。7 个月时，CD 组和对照组的血清转化率分别为 97%和 98.4%，几何平均滴度分别为 138.5 和 133 mIU/mL（P＞0.05）。CD 患儿最常见的 HLA 类型为 HLA-DQ2、-DR3 和 -DR7 等位基因，而对照组则为 HLA-DQ3、-DQ6、-DR11 和 -DR14。HLA 等位基因与甲型肝炎疫苗的抗体滴度之间无关联。