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[迟滞性疑病型精神分裂症的临床遗传学分析]

[Clinico-genetic analysis of sluggish hypochondriac schizophrenia].

作者信息

Serpukhovitina T V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(1):61-9.

PMID:2158730
Abstract

The clinicogenealogical method using a genetico-mathematic analysis was employed to examine 50 probands with sluggish hypochondriac schizophrenia (126 relatives of the first degree kinship). A study was made of the structure of familial accumulation of polar hypochondriac conditions (in continuum) of the varieties of sluggish schizophrenia: senestohypochondrias (25 families of probands) and neurotic hypochondrias (25 families of probands). The clinical polymorphism of sluggish hypochondriac schizophrenia correlated with the differences in accumulation, mainly by varieties of sluggish schizophrenia and personality abnormalities. It is concluded that analysis of the structure of familial accumulation in non-delirious hypochondriac conditions favours their typological differentiation, thereby enhancing the reliability of the clinical systematization.

摘要

采用遗传数学分析的临床系谱学方法对50例迟滞性疑病型精神分裂症先证者(126名一级亲属)进行了研究。对迟滞性精神分裂症各类型(连续谱)中极性疑病状态的家族聚集结构进行了研究:老年疑病症(25个先证者家族)和神经症性疑病症(25个先证者家族)。迟滞性疑病型精神分裂症的临床多态性与聚集差异相关,主要体现在迟滞性精神分裂症的类型和人格异常方面。得出结论:对非谵妄性疑病状态下家族聚集结构的分析有助于其类型学分化,从而提高临床系统化的可靠性。

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