Rotbart H A
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.
Annu Rev Med. 1990;41:25-34. doi: 10.1146/annurev.me.41.020190.000325.
The B19 strain of parvovirus causes several distinct and important clinical diseases in humans. Aplastic crisis in patients with chronic hemolytic anemia, persistent bone marrow depression in immunocompromised individuals, and hydrops fetalis all result from direct infection of hematopoietic cells by the virus. Erythema infectiosum, arthritis, and purpuric vasculitis are postinfectious manifestations of B19 parvovirus infection.
细小病毒B19株可引发人类几种不同且重要的临床疾病。慢性溶血性贫血患者的再生障碍危象、免疫功能低下个体的持续性骨髓抑制以及胎儿水肿均由该病毒直接感染造血细胞所致。传染性红斑、关节炎和紫癜性血管炎是B19细小病毒感染的感染后表现。