Brown K E, Young N S
Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Annu Rev Med. 1997;48:59-67. doi: 10.1146/annurev.med.48.1.59.
Parvovirus B19, the only known human pathogenic parvovirus, is associated with a wide range of disease manifestations. In healthy individuals, the major presentation of B19 infection is erythema infectiosum. In patients with underlying hemolytic disorders, infection is the primary cause of transient aplastic crisis. In immunosuppressed patients, persistent infection may develop that presents as pure red cell aplasia and chronic anemia. In utero infection may result in hydrops fetalis or congenital anemia. Diagnosis is based on examination of bone marrow and virologic studies. Much is known of the pathophysiology of the virus, and studies are in progress to develop a vaccine to prevent this widespread infection.
细小病毒B19是唯一已知的人类致病性细小病毒，与多种疾病表现相关。在健康个体中，B19感染的主要表现为传染性红斑。在患有潜在溶血性疾病的患者中，感染是短暂性再生障碍危象的主要原因。在免疫抑制患者中，可能会发生持续感染，表现为纯红细胞再生障碍和慢性贫血。宫内感染可能导致胎儿水肿或先天性贫血。诊断基于骨髓检查和病毒学研究。人们对该病毒的病理生理学了解很多，并且正在进行开发疫苗以预防这种广泛感染的研究。
