Hoffman P L, Rabe C S, Grant K A, Valverius P, Hudspith M, Tabakoff B
National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, Bethesda, MD 20892.
Alcohol. 1990 May-Jun;7(3):229-31. doi: 10.1016/0741-8329(90)90010-a.
The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor. Following chronic ethanol ingestion, the number of NMDA receptor-ion channel complexes in certain brain areas is increased. This increase may contribute to the generation of ethanol withdrawal seizures, since administration of an NMDA receptor antagonist can reduce these seizures. The results suggest that certain acute behavioral effects of ethanol, such as effects on memory, as well as certain aspects of ethanol withdrawal, may involve the NMDA receptor.
谷氨酸是中枢神经系统中主要的兴奋性氨基酸，其作用由三种受体亚型介导：海人藻酸、quisqualate和N-甲基-D-天冬氨酸（NMDA）受体。在体外，乙醇是NMDA受体激动剂作用的强效选择性抑制剂。长期摄入乙醇后，某些脑区中NMDA受体-离子通道复合物的数量会增加。这种增加可能导致乙醇戒断性癫痫发作，因为给予NMDA受体拮抗剂可减少这些癫痫发作。结果表明，乙醇的某些急性行为效应，如对记忆的影响，以及乙醇戒断的某些方面，可能涉及NMDA受体。
