小细胞肺癌中的神经元特异性烯醇化酶（NSE）：一种具有预后意义的肿瘤标志物？
Neurone specific enolase (NSE) in small cell lung cancer: a tumour marker of prognostic significance?
作者信息
Harding M, McAllister J, Hulks G, Vernon D, Monie R, Paul J, Kaye S B
机构信息
Department of Medical Oncology, University of Glasgow, UK.
出版信息
Br J Cancer. 1990 Apr;61(4):605-7. doi: 10.1038/bjc.1990.134.
Abstract
Pretreatment serum levels of neurone specific enolase (NSE) were measured in patients with small cell lung cancer (SCLC). Median values were significantly higher in patients with extensive compared with limited stage disease (48 ng ml-1 v. 17 ng ml-1: P less than 0.001). Serial NSE levels paralleled the clinical response to treatment. In 37 patients with limited SCLC, receiving identical chemotherapy, the pretreatment NSE level was of prognostic significance: with an approximate reduction in median survival of 10% for each 5 ng ml-1 incremental rise in NSE (P = 0.004).
摘要
对小细胞肺癌（SCLC）患者测量了神经元特异性烯醇化酶（NSE）的治疗前血清水平。广泛期疾病患者的中位数水平显著高于局限期疾病患者（48 ng/ml对17 ng/ml：P<0.001）。NSE水平的系列变化与治疗的临床反应平行。在37例接受相同化疗的局限期SCLC患者中，治疗前NSE水平具有预后意义：NSE每增加5 ng/ml，中位生存期大约降低10%（P = 0.004）。
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