血清神经元特异性烯醇化酶在小细胞肺癌中的预后影响
The prognostic influence of serum neuron specific enolase in small cell lung cancer.
作者信息
Jørgensen L G, Osterlind K, Hansen H H, Cooper E H
机构信息
Department of Oncology ONB, Finsen Institute, Rigshospitalet, Copenhagen, Denmark.
出版信息
Br J Cancer. 1988 Dec;58(6):805-7. doi: 10.1038/bjc.1988.313.
Abstract
An analysis of prognostic factors in small cell lung cancer has been made using presentation data from 86 of 101 consecutive patients referred to The Finsen Institute for chemotherapy. Prognosis was in univariate analysis significantly correlated with performance status (PS), disease extent, serum lactate dehydrogenase (LDH), neuron specific enolase (NSE), alpha-1-acid glycoprotein and plasma sodium. Multivariate analysis, taking stage of disease into account, resulted in selection of PS and NSE as the most influential of the investigated variables. LDH was excluded as an independent prognosticator, but there was a strong correlation between the influence of LDH and NSE (coefficient: -0.38) as well as between their serum concentrations (coefficient: 0.72). LDH and NSE apparently have similar prognostic influence, and NSE seems superior to LDH. A firm conclusion should, however, await our investigation of a large series of patients.
摘要
利用转诊至芬森研究所接受化疗的101例连续患者中的86例患者的就诊数据，对小细胞肺癌的预后因素进行了分析。在单因素分析中，预后与体能状态（PS）、疾病范围、血清乳酸脱氢酶（LDH）、神经元特异性烯醇化酶（NSE）、α-1-酸性糖蛋白和血浆钠显著相关。多因素分析考虑了疾病分期，结果选择PS和NSE作为所研究变量中最具影响力的因素。LDH被排除作为独立的预后指标，但LDH和NSE的影响之间存在很强的相关性（系数：-0.38），以及它们的血清浓度之间也存在很强的相关性（系数：0.72）。LDH和NSE显然具有相似的预后影响，且NSE似乎优于LDH。然而，要得出确切结论尚需我们对大量患者进行研究。
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