Tamura T, Machii K, Ueda K, Fujiwara K
Microbiol Immunol. 1978;22(9):557-64. doi: 10.1111/j.1348-0421.1978.tb00403.x.
In nude mice experimentally infected with mouse hepatitis virus (MHV), the numbers of early and later plaque forming cells (PFC) to sheep red blood cells (SRBC) generated in the spleen were 7 to 20 times and 2 to 163 times, respectively, greater than those in non-infected nude mice, when SRBC were given at day 0 to day 21 postinfection. Splenic theta-positive lymphocytes in infected nude mice were shown to increase only at day 10 or more postinfection. PFC response to bacterial lipopolysaccharide, a T cell-independent antigen, was not modified in MHV-infected nude mice.
在实验性感染小鼠肝炎病毒（MHV）的裸鼠中，当在感染后第0天至第21天给予绵羊红细胞（SRBC）时，脾脏中产生的针对绵羊红细胞的早期和晚期空斑形成细胞（PFC）数量分别比未感染的裸鼠高7至20倍和2至163倍。感染的裸鼠脾脏中的θ阳性淋巴细胞仅在感染后第10天及以后增加。对细菌脂多糖（一种非T细胞依赖性抗原）的PFC反应在MHV感染的裸鼠中未改变。
