Tamura T, Fujiwara K
Microbiol Immunol. 1979;23(3):177-83. doi: 10.1111/j.1348-0421.1979.tb00454.x.
In nude mice which originally had no ability to respond to sheep red blood cells, an enhanced response to the same antigen with IgM-IgG switching was demonstrated during subacute infection with mouse hepatitis virus. IgM antibody-producing cells in the spleen were detected at days 2 to 6 after the antigen injection and IgG antibody-producing cells appeared at day 6 or later. The secondary IgG response, though not remarkable, was recognized after reinjection of the antigen 10 days after the first injection.
在原本对绵羊红细胞无反应能力的裸鼠中，在感染小鼠肝炎病毒的亚急性期，对相同抗原的反应增强，并出现了IgM向IgG的转换。在抗原注射后第2至6天可检测到脾脏中产生IgM抗体的细胞，而产生IgG抗体的细胞在第6天或之后出现。在首次注射抗原10天后再次注射抗原后，可观察到次级IgG反应，尽管不显著。
