Hitosugi-Levesque Marina, Tanski Joseph M
Department of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.
Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 18;66(Pt 9):m1098-9. doi: 10.1107/S1600536810031144.
The title compound, Au(C(18)H(27)ClN(3))(C(18)H(15)P)(2), is a coordination complex of gold(I) triphenyl-phosphine with the N atom in the quinoline ring of the common anti-malarial compound chloro-quine (CQ). The pendant diethyl-amino group of the CQ ligand was found to be protonated. The complex exhibits a nearly linear coordination geometry around the Au(I) atom [N-Au-P = 176.94 (6)°], with Au-N and Au-P bond lengths of 2.070 (2) and 2.2338 (7) Å, respectively. The diethylammonium group and one of the two nitrate counter-ions are disordered with occupancy ratios of 0.519 (4):0.481 (4). The nitrate anions are hydrogen bound to both the amino and ammonium groups of the N,N-diethylpentanaminium fragment of the CQ.
标题化合物Au(C₁₈H₂₇ClN₃)(C₁₈H₁₅P)₂是金(I)三苯基膦与常见抗疟化合物氯喹（CQ）喹啉环中的N原子形成的配位络合物。发现CQ配体的悬垂二乙氨基被质子化。该络合物在Au(I)原子周围呈现出近乎线性的配位几何构型[N-Au-P = 176.94 (6)°]，Au-N和Au-P键长分别为2.070 (2) Å和2.2338 (7) Å。二乙铵基团和两个硝酸根抗衡离子中的一个存在无序，占有率分别为0.519 (4):0.481 (4)。硝酸根阴离子与CQ的N,N-二乙基戊铵片段的氨基和铵基均形成氢键。
