Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Semin Neurol. 2011 Apr;31(2):158-68. doi: 10.1055/s-0031-1277988. Epub 2011 May 17.
Recent identification of syndromes encompassing psychiatric symptoms, seizures, and movement disorders has led to effective treatments for several previously obscure conditions now known to be immune-mediated encephalopathies. In contrast to long-recognized paraneoplastic neurologic syndromes associated with antibodies to intracellular antigens, these more recently described disorders are not always paraneoplastic, are associated with cell surface antibodies, and may respond to immunosuppressive therapies. In this review, the author discusses clinical presentations, differential diagnosis, immunologic evaluation, and therapeutic options for both groups of disorders.
近期，一些包含精神症状、癫痫和运动障碍的综合征被识别出来，这使得一些以前不明确的免疫介导性脑病得到了有效的治疗。与长期被认可的与细胞内抗原抗体相关的副肿瘤性神经综合征不同，这些最近描述的疾病并不总是副肿瘤性的，与细胞表面抗体有关，并且可能对免疫抑制治疗有反应。在这篇综述中，作者讨论了这两组疾病的临床表现、鉴别诊断、免疫评估和治疗选择。
