Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA.
J Bone Miner Res. 2011 Sep;26(9):2307-16. doi: 10.1002/jbmr.430.
Osteoporosis affects all populations, but the risk for low bone density and fracture varies greatly by self-reported race and ethnicity. In this article, the relationship between measured percent African admixture and hip structural geometry, estimated from the hip structural analysis (HSA) program, was examined in a subcohort of the Women's Health Initiative (WHI). The study sample included 793 African-American women and 8559 non-Hispanic white women. All the participants were postmenopausal, between the ages of 50 and 79 years, at the time of recruitment and were followed for up to 9 years. Bone density and hip geometry were assessed using dual-energy X-ray absorptiometry. African admixture was measured for African Americans using genetic ancestry informative markers. Multiple regression and mixed-effects models were used for cross-sectional and longitudinal analyses, respectively. Covariates assessed from questionnaires and physical measurements were included in the analysis to control for possible confounding effects. The study results show significant correlations between percent of African admixture and HSA assessments. In comparison with non-Hispanic white women, significantly greater bone strength, as indicated by higher hip bone mineral density and stronger hip geometry, in women with higher African admixture was observed. However, women with higher percent African admixture had larger reductions in bone strength than non-Hispanic white women during the follow-up.
骨质疏松症影响所有人群，但基于自我报告的种族和民族，低骨密度和骨折的风险差异很大。在本文中，通过髋结构分析（HSA）程序，从髋结构分析中评估了测量的非洲混合百分比与髋结构几何形状之间的关系，这是妇女健康倡议（WHI）的一个子队列研究。研究样本包括 793 名非裔美国女性和 8559 名非西班牙裔白人女性。所有参与者均处于绝经后状态，招募时年龄在 50 至 79 岁之间，随访时间长达 9 年。使用双能 X 射线吸收法评估骨密度和髋部几何形状。使用遗传祖先信息标记来测量非裔美国人的非洲混合百分比。分别使用多元回归和混合效应模型进行横断面和纵向分析。问卷调查和体格测量评估的协变量包含在分析中，以控制可能的混杂影响。研究结果表明，非洲混合百分比与 HSA 评估之间存在显著相关性。与非西班牙裔白人女性相比，具有更高非洲混合百分比的女性表现出更高的髋骨矿物质密度和更强的髋部几何形状，这表明骨强度更高。然而，在随访期间，具有更高非洲混合百分比的女性的骨强度下降幅度大于非西班牙裔白人女性。
